Domenico Plantone, Matteo Pardini, Stefano Caneva, Nicola De Stefano
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引用次数: 0
Abstract
Alzheimer's disease (AD) represents the most prevalent type of neurodegenerative dementia and the sixth leading cause of death worldwide. The so-called "non-calcemic actions" of vitamin D have been increasingly described, and its insufficiency has already been linked to the onset and progression of the main neurological diseases, including AD. Immune-mediated Aβ plaque's phagocytosis and clearance, immune response, oxidative stress, and mitochondrial function are all influenced by vitamin D, and these functions are considered relevant in AD pathogenesis. However, it has been shown that the genomic vitamin D signaling pathway is already impaired in the AD brain, making things more complicated. In this paper, we aim to summarise the role of vitamin D in AD and review the results of the supplementation trials in AD patients.
阿尔茨海默病（AD）是最常见的神经退行性痴呆类型，也是全球第六大死亡原因。维生素 D 的所谓 "非降钙作用 "已被越来越多地描述出来，维生素 D 不足已与包括阿兹海默症在内的主要神经系统疾病的发病和进展联系在一起。免疫介导的 Aβ 斑块的吞噬和清除、免疫反应、氧化应激和线粒体功能均受维生素 D 的影响，这些功能被认为与 AD 的发病机制有关。然而，有研究表明，AD 大脑中的基因组维生素 D 信号通路已经受损，这使得情况变得更加复杂。在本文中，我们旨在总结维生素D在AD中的作用，并回顾AD患者补充维生素D试验的结果。
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Aims & Scope
CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.
CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.
As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.
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