Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-Coding RNA Pub Date : 2023-03-09 DOI:10.3390/ncrna9020019

Yanyan Wang, Jing Zeng, Weidong Chen, Jiangao Fan, Phillip B Hylemon, Huiping Zhou

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Abstract

Liver cancer is the second leading cause of cancer-related death globally, with limited treatment options. Recent studies have demonstrated the critical role of long noncoding RNAs (lncRNAs) in the pathogenesis of liver cancers. Of note, mounting evidence has shown that lncRNA H19, an endogenous noncoding single-stranded RNA, functions as an oncogene in the development and progression of liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), the two most prevalent primary liver tumors in adults. H19 can affect many critical biological processes, including the cell proliferation, apoptosis, invasion, and metastasis of liver cancer by its function on epigenetic modification, H19/miR-675 axis, miRNAs sponge, drug resistance, and its regulation of downstream pathways. In this review, we will focus on the most relevant molecular mechanisms of action and regulation of H19 in the development and pathophysiology of HCC and CCA. This review aims to provide valuable perspectives and translational applications of H19 as a potential diagnostic marker and therapeutic target for liver cancer disease.

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长非编码 RNA H19：肝癌中的新型癌基因

肝癌是全球癌症相关死亡的第二大原因，但治疗方法却很有限。最近的研究表明，长非编码 RNA（lncRNA）在肝癌的发病机制中起着至关重要的作用。值得注意的是，越来越多的证据表明，lncRNA H19 是一种内源性非编码单链 RNA，在肝癌（包括肝细胞癌（HCC）和胆管癌（CCA）这两种成人最常见的原发性肝肿瘤）的发生和发展过程中起着癌基因的作用。H19 可通过其表观遗传修饰、H19/miR-675 轴、miRNAs 海绵、耐药性及其对下游通路的调控等功能，影响许多关键的生物学过程，包括肝癌的细胞增殖、凋亡、侵袭和转移。在本综述中，我们将重点讨论 H19 在 HCC 和 CCA 的发展和病理生理学中最相关的分子作用和调控机制。本综述旨在为 H19 作为肝癌疾病的潜在诊断标志物和治疗靶点提供有价值的观点和转化应用。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.

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