Metabolic Regulation of Immune Response and Tissue Remodeling in Gouty Arthritis (Review).

IF 1.5 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Eukaryotic Gene Expression Pub Date : 2023-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2022046409
Ziyi Chen, Wenjuan Wang, Yinghui Hua
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Abstract

Gouty arthritis (GA), one of the most common forms of inflammatory arthritis, is characterized by elevated serum uric acid concentrations and the consequent deposition of monosodium urate crystals. Under low-grade inflammatory stress, cells tend to adapt to the microenvironment by reprogramming their metabolic pathways. Here we review the aberrant metabolic responses to the inflammatory environment in immune and tissue cells in distinct phases of GA. Regulation of these pathways is implicated in metabolic alterations including mitochondrial dysfunction, changes in the glycolytic pathway, and alteration of lipid, uric acid, and bone metabolism among others. Investigations of how these alterations lead to proinflammatory and anti-inflammatory effects in each period of GA have revealed links to its pathogenesis. Knowledge gained may open up new opportunities for diagnosis, treatment and prognosis of GA and offer rationale for further investigation into the mechanisms underlying the progression of the disease.

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痛风性关节炎免疫反应和组织重塑的代谢调节(综述)。
痛风性关节炎(GA)是炎症性关节炎最常见的形式之一,其特点是血清尿酸浓度升高,并随之沉积尿酸钠晶体。在低级别炎症应激下,细胞倾向于通过重新编程其代谢途径来适应微环境。本文回顾了GA不同阶段免疫细胞和组织细胞对炎症环境的异常代谢反应。这些途径的调控涉及代谢改变,包括线粒体功能障碍、糖酵解途径的改变、脂质、尿酸和骨代谢等的改变。这些改变如何导致GA各个时期的促炎和抗炎作用的研究揭示了其发病机制的联系。所获得的知识可能为GA的诊断、治疗和预后开辟新的机会,并为进一步研究疾病进展的机制提供依据。
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来源期刊
Critical Reviews in Eukaryotic Gene Expression
Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物
CiteScore
2.70
自引率
0.00%
发文量
67
审稿时长
1 months
期刊介绍: Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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