The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats.

IF 1.7 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology Pub Date : 2023-03-01 DOI:10.2478/aiht-2023-74-3697
Antonija Vukšić, Dubravka Rašić, Suzana Žunec, Tamara Božina, Paško Konjevoda, Jasna Lovrić, Marinko Bilušić, Vlasta Bradamante
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Abstract

The objective of study was to investigate the effects of different doses of simvastatin and fenofibrate on malondialdehyde (MDA) and reduced glutathione (GSH) in the plasma, liver, and brain tissue of male normolipidaemic and hyperlipidaemic rats. Normolipidaemic (Wistar) rats were receiving 10 or 50 mg/kg a day of simvastatin or 30 or 50 mg/kg a day of fenofibrate. Hyperlipidaemic (Zucker) rats were receiving 50 mg/kg/day of simvastatin or 30 mg/kg/day of fenofibrate. Control normolipidaemic and hyperlipidaemic rats were receiving saline. Simvastatin, fenofibrate, and saline were administered by gavage for three weeks. In normolipidaemic rats simvastatin and fenofibrate showed similar and dose-independent effects on plasma and brain MDA and GSH concentrations. Generally, plasma and brain MDA decreased, while brain GSH concentration increased. In hyperlipidaemic rats simvastatin did not affect plasma and brain MDA and GSH concentrations but significantly decreased liver GSH. Fenofibrate decreased plasma and liver MDA but increased brain MDA. In both rat strains fenofibrate significantly decreased liver GSH concentrations, most likely because fenofibrate metabolites bind to GSH. Our findings suggest that simvastatin acts as an antioxidant only in normolipidaemic rats, whereas fenofibrate acts as an antioxidant in both rat strains.

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辛伐他汀和非诺贝特对正常血脂和高血脂大鼠血浆、肝脏和脑中丙二醛和还原性谷胱甘肽浓度的影响
本研究旨在探讨不同剂量辛伐他汀和非诺贝特对正常血脂和高血脂雄性大鼠血浆、肝脏和脑组织中丙二醛(MDA)和还原性谷胱甘肽(GSH)的影响。正常血脂(Wistar)大鼠每天接受10或50 mg/kg辛伐他汀或30或50 mg/kg非诺贝特。高脂血症(Zucker)大鼠接受50 mg/kg/天辛伐他汀或30 mg/kg/天非诺贝特。正常血脂和高脂血症对照大鼠给予生理盐水。辛伐他汀、非诺贝特、生理盐水灌胃3周。在正常血脂大鼠中,辛伐他汀和非诺贝特对血浆和脑MDA和GSH浓度的影响相似且剂量无关。血浆和脑MDA降低,脑GSH浓度升高。在高脂血症大鼠中,辛伐他汀不影响血浆和脑MDA和GSH浓度,但显著降低肝脏GSH。非诺贝特降低血浆和肝脏MDA,但增加脑MDA。在这两种大鼠菌株中,非诺贝特显著降低了肝脏GSH浓度,很可能是因为非诺贝特的代谢物与GSH结合。我们的研究结果表明,辛伐他汀仅在正常血脂大鼠中起抗氧化作用,而非诺贝特在两种大鼠品系中都起抗氧化作用。
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来源期刊
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology
Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-TOXICOLOGY
CiteScore
3.50
自引率
4.80%
发文量
26
审稿时长
6-12 weeks
期刊介绍: Archives of Industrial Hygiene and Toxicology (abbr. Arh Hig Rada Toksikol) is a peer-reviewed biomedical scientific quarterly that publishes contributions relevant to all aspects of environmental and occupational health and toxicology.
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