Yuan Wang , Graham Herzig , Cassandra Molano , Aimin Liu
{"title":"Differential expression of the Tmem132 family genes in the developing mouse nervous system","authors":"Yuan Wang , Graham Herzig , Cassandra Molano , Aimin Liu","doi":"10.1016/j.gep.2022.119257","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The family of novel transmembrane proteins (TMEM) 132 have been associated with multiple </span>neurological disorders and cancers in humans, but have hardly been studied in vivo. Here we report the expression patterns of the five </span><em>Tmem132</em><span><span> genes (a, b, c, d and e) in developing mouse nervous system with </span>RNA<span> in situ hybridization in wholemount embryos and tissue sections. Our results reveal differential and partially overlapping expression of multiple </span></span><em>Tmem132</em> family members in both the central and peripheral nervous system, suggesting potential partial redundancy among them.</p></div>","PeriodicalId":55598,"journal":{"name":"Gene Expression Patterns","volume":"45 ","pages":"Article 119257"},"PeriodicalIF":1.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene Expression Patterns","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1567133X22000278","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The family of novel transmembrane proteins (TMEM) 132 have been associated with multiple neurological disorders and cancers in humans, but have hardly been studied in vivo. Here we report the expression patterns of the five Tmem132 genes (a, b, c, d and e) in developing mouse nervous system with RNA in situ hybridization in wholemount embryos and tissue sections. Our results reveal differential and partially overlapping expression of multiple Tmem132 family members in both the central and peripheral nervous system, suggesting potential partial redundancy among them.
期刊介绍：
Gene Expression Patterns is devoted to the rapid publication of high quality studies of gene expression in development. Studies using cell culture are also suitable if clearly relevant to development, e.g., analysis of key regulatory genes or of gene sets in the maintenance or differentiation of stem cells. Key areas of interest include:
-In-situ studies such as expression patterns of important or interesting genes at all levels, including transcription and protein expression
-Temporal studies of large gene sets during development
-Transgenic studies to study cell lineage in tissue formation
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
