Intraocular Lens and Lens Capsule Spread of Iridociliary Melanoma: Clinical and Histopathologic Features of 2 Cases.

Pub Date : 2022-06-01 DOI:10.1159/000524052

Corrina P Azarcon, Jill R Wells, Thomas Aaberg, Hans E Grossniklaus

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Abstract

Purpose: The aim of this study was to describe 2 patients with intraocular lens (IOL) and lens capsule spread of iridociliary melanoma.

Methods: Two pseudophakic patients with iridociliary body melanoma that spread onto the surface of their IOL and remaining lens capsule were included. Their eyes were enucleated and the histopathologic features were evaluated.

Results: Case 1 was an 82-year-old woman with diffuse primary iridociliary melanoma affecting the iris, lens capsule, IOL surface, and ciliary body. Case 2 was a 68-year-old female who developed melanoma recurrence in the anterior segment after plaque brachytherapy for iridociliary melanoma. The melanoma in both cases grew as a pigmented membrane onto the surface of the IOL.

Conclusions: IOL and lens capsule spread of iridociliary melanoma can occur primarily or develop secondarily after plaque brachytherapy of a pseudophakic eye. Since the extent of the melanoma may be uncertain and there is a high likelihood of glaucoma, enucleation is a reasonable option.

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虹膜睫状体黑色素瘤的晶状体和晶状体囊扩散:2例临床和组织病理学特征。

目的:对2例虹膜睫状体黑色素瘤合并人工晶状体及晶状体囊扩散的病例进行分析。方法:选取2例假晶状体伴虹膜睫状体黑色素瘤扩散至人工晶状体表面及剩余晶状体囊的患者。取眼球去核，观察组织病理特征。结果:病例1是一名82岁女性，患有弥漫性原发性虹膜睫状体黑色素瘤，累及虹膜、晶状体囊、人工晶状体表面和睫状体。病例2是一名68岁的女性，在虹膜睫状体黑色素瘤的斑块近距离治疗后，在前段出现黑色素瘤复发。这两例患者的黑色素瘤都以色素膜的形式生长在人工晶状体表面。结论:虹膜睫状体黑色素瘤的人工晶状体和晶状体囊扩散可在假性晶状眼斑块近距离治疗后发生或继发。由于黑色素瘤的范围可能不确定，并且青光眼的可能性很高，因此摘除是一种合理的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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