Deep white matter hyperintensity is spatially correlated to MRI-visible perivascular spaces in cerebral small vessel disease on 7 Tesla MRI.

IF 4.4 1区 医学 Q1 CLINICAL NEUROLOGY Stroke and Vascular Neurology Pub Date : 2023-04-01 DOI:10.1136/svn-2022-001611
Yajing Huo, Yilin Wang, Cen Guo, Qianyun Liu, Lili Shan, Mingyuan Liu, Haibo Wu, Guanwu Li, Huihui Lv, Lingdan Lu, Yintin Zhou, Jianfeng Feng, Yan Han
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引用次数: 1

Abstract

Background: The association between perivascular space (PVS) and white matter hyperintensity (WMH) has been unclear. Normal-appearing white matter (NAWM) around WMH is also found correlated with the development of focal WMH. This study aims to investigate the topological connections among PVS, deep WMH (dWMH) and NAWM around WMH using 7 Tesla (7T) MRI.

Methods: Thirty-two patients with non-confluent WMHs and 16 subjects without WMHs were recruited from our department and clinic. We compared the PVS burden between patients with and without WMHs using a 5-point scale. Then, the dilatation and the number of PVS within a radius of 1 cm around each dWMH were compared with those of a reference site (without WMH) in the contralateral hemisphere. In this study, we define NAWM as an area within the radius of 1 cm around each dWMH. Furthermore, we assessed the spatial relationship between dWMH and PVS.

Results: Higher PVS scores in the centrum semiovale were found in patients with >5 dWMHs (median 3) than subjects without dWMH (median 2, p = 0.014). We found there was a greater dilatation and a higher number of PVS in NAWM around dWMH than at the reference sites (p<0.001, p<0.001). In addition, 79.59% of the dWMHs were spatially connected with PVS.

Conclusion: dWMH, NAWM surrounding WMH and MRI-visible PVS are spatially correlated in the early stage of cerebral small vessel disease. Future study of WMH and NAWM should not overlook MRI-visible PVS.

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在7特斯拉MRI上,脑小血管病变的深部白质高强度与MRI可见血管周围间隙在空间上相关。
背景:血管周围间隙(PVS)与白质高强度(WMH)之间的关系尚不清楚。WMH周围的正常白质(NAWM)也被发现与局灶性WMH的发展有关。本研究旨在利用7特斯拉(7T) MRI研究PVS、深度WMH (dWMH)和WMH周围NAWM之间的拓扑联系。方法:从我科和临床选取32例非合流性腰痛患者和16例非合流性腰痛患者。我们使用5分制比较了有和没有wmh患者的PVS负担。然后,与对侧半球参考部位(无WMH)比较每个dWMH周围1 cm半径内的扩张和PVS数量。在本研究中,我们将NAWM定义为每个dWMH周围1厘米半径内的区域。此外,我们还评估了dWMH与PVS之间的空间关系。结果:>5个dWMH患者(中位数为3)比无dWMH患者(中位数为2,p = 0.014)半膈中心PVS评分更高。我们发现,与参考部位相比,dWMH周围的NAWM扩张更大,PVS数量更多(p结论:dWMH、WMH周围的NAWM和mri可见的PVS在早期脑血管病中具有空间相关性。未来对WMH和NAWM的研究不应忽视mri可见pv。
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来源期刊
Stroke and Vascular Neurology
Stroke and Vascular Neurology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
11.20
自引率
1.70%
发文量
63
审稿时长
15 weeks
期刊介绍: Stroke and Vascular Neurology (SVN) is the official journal of the Chinese Stroke Association. Supported by a team of renowned Editors, and fully Open Access, the journal encourages debate on controversial techniques, issues on health policy and social medicine.
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