ENLARGEMENT OF CHOROIDAL NEOVASCULARIZATION BEFORE RECURRENCE AFTER PHOTODYNAMIC THERAPY FOR PACHYCHOROID NEOVASCULOPATHY.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-09-01 DOI:10.1097/IAE.0000000000003841

Taiichi Hikichi, Natsuki Kubo, Moe Tabata, Haruka Kurabe

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Abstract

Purpose: To investigate predictors of recurrent exudation in choroidal neovascularization (CNV) of pachychoroid neovasculopathy after photodynamic therapy (PDT).

Methods: Consecutive, treatment-naïve, symptomatic patients with pachychoroid neovasculopathy with subfoveal retinal fluid treated with PDT and followed for 18 months were studied retrospectively. Choroidal neovascularization areas were calculated from optical coherence tomography angiography images obtained at various time points after the initial PDT.

Results: In 52 eyes, the subfoveal retinal fluid resolved completely three months after PDT; in 23 (44%) eyes, exudation recurred during the 18-month follow-up period. In 29 eyes with no recurrence, the mean baseline square root of the CNV area of 1.91 mm (95% CI, 0.27) decreased significantly ( P = 0.006) to 1.47 mm (95% CI, 0.16) at three months after PDT and decreased further until 12 months after PDT (mean, 1.26 mm; 95% CI, P < 0.001) and was maintained thereafter. In 23 eyes with a recurrence, the square root of the CNV area enlarged significantly ( P = 0.028) from 1.43 mm (95% CI, 0.21) at examination three months before the recurrence to 1.73 mm (95% CI, 0.18) at recurrence.

Conclusion: Choroidal neovascularization enlargement during the follow-up period after PDT for pachychoroid neovasculopathy may predict recurrence.

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光动力疗法治疗脉络膜新生血管病变后复发前脉络膜新生血管扩大。

目的：研究光动力疗法（PDT）后脉络膜新生血管（CNV）的复发性渗出的预测因素：方法：对连续接受光动力疗法治疗的、未接受过治疗的、有症状的、伴有视网膜下积液的脉络膜新生血管病患者进行回顾性研究，并随访18个月。根据首次 PDT 治疗后不同时间点获得的光学相干断层血管造影图像计算脉络膜新生血管面积：52只眼睛的视网膜下积液在PDT三个月后完全消退；23只眼睛（44%）的渗出在18个月的随访期间复发。在 29 只未复发的眼睛中，CNV 面积的平均基线平方根为 1.91 毫米（95% CI，0.27），在 PDT 三个月后显著下降（P = 0.006）至 1.47 毫米（95% CI，0.16），并在 PDT 12 个月前进一步下降（平均为 1.26 毫米；95% CI，P < 0.001），此后保持不变。在复发的 23 只眼睛中，CNV 面积的平方根显著增大（P = 0.028），从复发前三个月检查时的 1.43 毫米（95% CI，0.21）增至复发时的 1.73 毫米（95% CI，0.18）：结论：PDT 治疗脉络膜新生血管病变后的随访期间，脉络膜新生血管扩大可能预示着复发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.