Analysis and risk assessment of vinyl chloride emitted from aerosol products.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1080/10934529.2023.2173925

Naeko Sugaya, Kaoru Inoue, Maiko Tahara, Tsuyoshi Kawakami

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Abstract

The objectives of this study were to develop a novel analytical method for quantifying vinyl chloride (VC) emitted from aerosol products, to provide analytical data on VC in aerosol products, and to evaluate consumer VC exposure by aerosol products. Our quantitative method involves absorbing VC into dimethyl sulfoxide and analyzing it using headspace gas chromatography/mass spectrometry. The correlation coefficients of the VC calibration curves were ≥ 0.9994 in the range of 0.16-80 µg/mL VC standard gases, which were prepared under either nitrogen or emission gases containing dimethyl ether or liquid petroleum gas. VC concentrations in these emission gases were calculated using a VC calibration curve from standard gases prepared under nitrogen; they were within ± 10% of the actual concentrations. We analyzed 39 household aerosol products; VC concentrations of 0.095, 0.098, and 0.28 μg/L were detected in three polyvinyl chloride spray paints. Consumer VC inhalation exposure level was estimated through an exposure scenario, and the hazard quotient was confirmed to be very low when comparing the exposure level with a cancer risk level of 10^-5 for inhaled VC. These results suggest that the human health risk from VC in spray paint was low.

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气溶胶产品中氯乙烯排放的分析与风险评估。

本研究的目的是建立一种新的定量气溶胶产品中氯乙烯(VC)的分析方法，提供气溶胶产品中氯乙烯的分析数据，并评估消费者对气溶胶产品中氯乙烯的暴露。我们的定量方法包括将VC吸收到二甲亚砜中，并使用顶空气相色谱/质谱法进行分析。在0.16 ~ 80µg/mL VC标准气体范围内，在含氮气或含二甲醚或液化石油气的排放气体条件下制备的VC校准曲线相关系数均≥0.9994。利用氮条件下制备的标准气体的VC校准曲线计算了这些排放气体中的VC浓度;它们在实际浓度的±10%以内。我们分析了39种家用气溶胶产品;三种聚氯乙烯喷漆中VC浓度分别为0.095、0.098和0.28 μg/L。通过暴露情景估计消费者的VC吸入暴露水平，并将暴露水平与吸入VC的10-5的癌症风险水平进行比较，确认危害商非常低。这些结果表明，喷漆中VC对人体健康的风险较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.