Creating and sensing asymmetric lipid distributions throughout the cell.

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Emerging Topics in Life Sciences Pub Date : 2023-03-31 DOI:10.1042/ETLS20220028
Guillaume Drin
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引用次数: 3

Abstract

A key feature of eukaryotic cells is the asymmetric distribution of lipids along their secretory pathway. Because of the biological significance of these asymmetries, it is crucial to define the mechanisms which create them. Extensive studies have led to the identification of lipid transfer proteins (LTPs) that work with lipid-synthesizing enzymes to carry lipids between two distinct membranes in a directional manner, and are thus able to create asymmetries in lipid distribution throughout the cell. These networks are often in contact sites where two organelle membranes are in close proximity for reasons we have only recently started to understand. A question is whether these networks transfer lipids en masse within the cells or adjust the lipid composition of organelle membranes. Finally, recent data have confirmed that some networks organized around LTPs do not generate lipid asymmetries between membranes but sense them and rectify the lipid content of the cell.

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在整个细胞中产生和感知不对称的脂质分布。
真核细胞的一个关键特征是脂质沿其分泌途径的不对称分布。由于这些不对称的生物学意义,确定产生它们的机制是至关重要的。广泛的研究已经确定了脂质转移蛋白(LTPs),它与脂质合成酶一起以定向方式在两个不同的膜之间携带脂质,因此能够在整个细胞中产生脂质分布的不对称。这些网络通常位于两个细胞器膜靠近的接触部位,原因我们最近才开始了解。一个问题是这些网络是否在细胞内大量转移脂质或调节细胞器膜的脂质组成。最后,最近的数据证实,围绕ltp组织的一些网络不会在膜之间产生脂质不对称,而是感知它们并纠正细胞的脂质含量。
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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
94
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