{"title":"[Radiotherapy for the treatment of leukemia].","authors":"Michael Oertel, Hans Theodor Eich","doi":"10.1007/s00761-022-01163-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lymphoma cells are highly radiosensitive and consequently, radiation therapy is a rational addition to systemic therapy in the treatment of leukemia. Especially as a conditioning regimen before allogeneic stem cell transplantation, radiation therapy, in the form of total body irradiation, is an established concept.</p><p><strong>Objectives: </strong>The present work provides an overview on the execution and side effects of radiation treatment in leukemia. Especially (long-term) side effects after total body irradiation are presented.</p><p><strong>Materials and methods: </strong>A selective search in the database PubMed on radiation treatment of leukemia and on total body irradiation has been carried out, focusing on toxicities as well as technical and conceptional innovations.</p><p><strong>Results: </strong>Total body irradiation is a successful conditioning therapy before allogeneic stem cell transplantation and is accompanied by a diverse, but manageable, toxicity spectrum with endocrinological, cardiopulmonary, ophthalmological, nephrological and neurological long-term side effects as well as secondary neoplasia. In addition, low-dose radiotherapy may be utilized to treat myeloid sarcoma (chloroma).</p><p><strong>Conclusions: </strong>The variety of side effects after total body irradiation requires an interdisciplinary and long-term aftercare provided by radiation oncologists and medical oncologists/the transplantation team. Technical evolutions may result in a more selective targeting of the bone marrow and lymphatic organs. At the moment, these techniques are not established in clinical routine but are being evaluated in clinical trials.</p>","PeriodicalId":44016,"journal":{"name":"GYNAKOLOGE","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035974/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"GYNAKOLOGE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00761-022-01163-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Lymphoma cells are highly radiosensitive and consequently, radiation therapy is a rational addition to systemic therapy in the treatment of leukemia. Especially as a conditioning regimen before allogeneic stem cell transplantation, radiation therapy, in the form of total body irradiation, is an established concept.
Objectives: The present work provides an overview on the execution and side effects of radiation treatment in leukemia. Especially (long-term) side effects after total body irradiation are presented.
Materials and methods: A selective search in the database PubMed on radiation treatment of leukemia and on total body irradiation has been carried out, focusing on toxicities as well as technical and conceptional innovations.
Results: Total body irradiation is a successful conditioning therapy before allogeneic stem cell transplantation and is accompanied by a diverse, but manageable, toxicity spectrum with endocrinological, cardiopulmonary, ophthalmological, nephrological and neurological long-term side effects as well as secondary neoplasia. In addition, low-dose radiotherapy may be utilized to treat myeloid sarcoma (chloroma).
Conclusions: The variety of side effects after total body irradiation requires an interdisciplinary and long-term aftercare provided by radiation oncologists and medical oncologists/the transplantation team. Technical evolutions may result in a more selective targeting of the bone marrow and lymphatic organs. At the moment, these techniques are not established in clinical routine but are being evaluated in clinical trials.
期刊介绍：
Zielsetzung der Zeitschrift
Der Gynäkologe ist ein angesehenes Publikationsorgan und wendet sich an Gynäkolog*innen in Praxis und Klinik. Die Zeitschrift bietet aktuelle Fortbildung aus allen Bereichen der Frauenheilkunde und Geburtshilfe einschließlich Themen der Endokrinologie und Reproduktionsmedizin. Ergänzt wird das inhaltliche Spektrum durch interdisziplinäre Fachgebiete und Nachbargebiete wie die Onkologie, Chirurgie oder Innere Medizin sowie durch die Rubrik "Medizinrecht".
Umfassende Übersichtsarbeiten zu einem aktuellen Schwerpunktthema sind das Kernstück jeder Ausgabe. Im Mittelpunkt steht dabei gesichertes Wissen zu Diagnostik und Therapie mit hoher Relevanz für die tägliche Arbeit - die Leser*innen erhalten konkrete Handlungsempfehlungen.
Die Rubrik "Frauengesundheit in der Praxis" behandelt fundiert Themen aus dem Arbeitsalltag der niedergelassenen Gynäkolog*innen.
Beiträge der Rubrik "CME Zertifizierte Fortbildung" bieten gesicherte Ergebnisse wissenschaftlicher Forschung und machen ärztliche Erfahrung für die tägliche Praxis nutzbar. Nach Lektüre der Beiträge können die Leser*innen ihr erworbenes Wissen überprüfen und online CME-Punkte erhalten. Die Rubrik orientiert sich an der Weiterbildungsordnung des Fachgebiets.
Aims & Scope
Der Gynäkologe is a respected publication organ for all gynecologists working in practical and clinical environments and scientists who are particularly interested in issues of gynecology.
The journal offers up-to-date information from all fields of gynecology and obstetrics including topics from the fields of endocrinology and reproductive medicine. The bandwidth of the journal’s content is complemented by interdisciplinary and related topics from oncology, surgery, internal medicine, and legal medicine.
Comprehensive reviews on a specific topical issue provide evidenced based information on diagnostics and therapy.
Review articles under the rubric "Continuing Medical Education" present verified results of scientific research and their integration into daily practice.
Review
All articles of Der Gynäkologe are reviewed.
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