Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners.

IF 5.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2022-12-01 DOI:10.1080/13510002.2022.2123882
Sebastian Bańkowski, Miroslav Petr, Michał Rozpara, Ewa Sadowska-Krępa
{"title":"Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners.","authors":"Sebastian Bańkowski,&nbsp;Miroslav Petr,&nbsp;Michał Rozpara,&nbsp;Ewa Sadowska-Krępa","doi":"10.1080/13510002.2022.2123882","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO<sub>2max</sub> and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle.</p><p><strong>Methods: </strong>Thirty runners were randomly assigned to a placebo group (PL) and a curcumin-supplemented group (CU). Their VO<sub>2max</sub> was assessed before supplementation and after 6 weeks of supplementation. Venous blood samples were collected from the participants at rest, immediately after exercise, and after 1h of recovery to evaluate the activity of antioxidant enzymes (SOD, CAT, GPx), non-enzymatic antioxidants (GSH, UA) and sirtuin 3 level (SIRT 3), as well as the levels of oxidative stress markers (TOS/TOC, MDA, and 8-OHdG) and muscle damage markers (CK, LDH, and Mb).</p><p><strong>Results: </strong>VO<sub>2max</sub>, the activity of enzymatic antioxidants, the concentrations of non-enzymatic antioxidants, the levels of oxidative stress markers, and the levels of muscle damage markers did not change significantly in the CU group over 6 weeks of supplementation with curcumin. However, the resting concentration of SIRT 3 was found to be significantly higher (p ≤ 0.05) compared with pre-supplementation.</p><p><strong>Conclusion: </strong>Curcumin supplementation does not have a significant effect on VO<sub>2max</sub> and prooxidant/antioxidant homeostasis in runners.</p>","PeriodicalId":21096,"journal":{"name":"Redox Report","volume":"27 1","pages":"186-192"},"PeriodicalIF":5.2000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518241/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Redox Report","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/13510002.2022.2123882","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 3

Abstract

Background: The study was undertaken to evaluate the effect of 6-week supplementation with a daily dose of 2g of curcumin on VO2max and prooxidant/antioxidant homeostasis in middle-aged amateur long-distance runners during the preparatory period of the macrocycle.

Methods: Thirty runners were randomly assigned to a placebo group (PL) and a curcumin-supplemented group (CU). Their VO2max was assessed before supplementation and after 6 weeks of supplementation. Venous blood samples were collected from the participants at rest, immediately after exercise, and after 1h of recovery to evaluate the activity of antioxidant enzymes (SOD, CAT, GPx), non-enzymatic antioxidants (GSH, UA) and sirtuin 3 level (SIRT 3), as well as the levels of oxidative stress markers (TOS/TOC, MDA, and 8-OHdG) and muscle damage markers (CK, LDH, and Mb).

Results: VO2max, the activity of enzymatic antioxidants, the concentrations of non-enzymatic antioxidants, the levels of oxidative stress markers, and the levels of muscle damage markers did not change significantly in the CU group over 6 weeks of supplementation with curcumin. However, the resting concentration of SIRT 3 was found to be significantly higher (p ≤ 0.05) compared with pre-supplementation.

Conclusion: Curcumin supplementation does not have a significant effect on VO2max and prooxidant/antioxidant homeostasis in runners.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
6周补充姜黄素对中年业余长跑运动员有氧能力、抗氧化状态和sirtuin 3水平的影响。
背景:本研究旨在评估在大周期准备阶段,中年业余长跑运动员在6周内每天补充2g姜黄素对VO2max和促氧化/抗氧化稳态的影响。方法:30名跑步者随机分为安慰剂组(PL)和姜黄素补充组(CU)。在补充前和补充6周后评估他们的VO2max。分别在休息、运动后和恢复后1小时采集静脉血,评估抗氧化酶(SOD、CAT、GPx)、非酶抗氧化剂(GSH、UA)和sirtuin 3水平的活性,以及氧化应激标志物(TOS/TOC、MDA和8-OHdG)和肌肉损伤标志物(CK、LDH和Mb)的水平。结果:在补充姜黄素6周后,CU组的VO2max、酶促抗氧化剂活性、非酶促抗氧化剂浓度、氧化应激标志物水平和肌肉损伤标志物水平均无显著变化。然而,与补充前相比,SIRT - 3的静息浓度显著升高(p≤0.05)。结论:补充姜黄素对跑步者的VO2max和促氧化/抗氧化稳态没有显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Redox Report
Redox Report 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
期刊最新文献
Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis. Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS-mediated signaling pathways. Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation. Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice. Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1