Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate.

IF 11.3 1区 医学 Q1 Medicine Biomaterials Research Pub Date : 2023-03-29 DOI:10.1186/s40824-023-00364-z
Song-Yi Yang, A Ruem Han, Ji-Won Choi, Kwang-Mahn Kim, Jae-Sung Kwon
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Abstract

Background: White Portland cement is a calcium silicate material. It exhibits antibacterial properties and is biocompatible. In addition, calcium silicate-based materials are known to release calcium ions and form apatite. The purpose of this study was to develop a novel bioactive restorative resin composite with antibacterial and apatite forming properties to prevent tooth caries at the interface of teeth and restorative materials, by incorporation of hydrated calcium silicate (hCS) derived from white Portland cement.

Methods: To prepare the experimental composite resins, a 30 wt% light-curable resin matrix and 70 wt% filler, which was mixed with hCS and silanized glass powder were prepared in following concentrations: 0, 17.5, 35.0, and 52.5 wt% hCS filler. The depth of cure, flexural strength, water sorption, solubility, and antibacterial effect were tested. After immersion in artificial saliva solution for 15, 30, 60, and 90 days, ion concentration by ICP-MS and apatite formation using SEM-EDS, Raman spectroscopy and XRD from experimental specimens were analyzed.

Results: All experimental groups showed clinically acceptable depths of cure and flexural strength for the use as the restorative composite resin. Water sorption, solubility, released Ca and Si ions increased with the addition of hCS to the experimental composite resin. Experimental groups containing hCS showed greater antibacterial effects compared with the 0 wt% hCS filler group (p < 0.05). The 52.5 wt% hCS filler group produced precipitates mainly composed of Ca and P detected as hydroxyapatite after immersion in artificial saliva solution for 30, 60, and 90 days.

Conclusions: This results show that composite resins containing hCS filler is effective in antibacterial effects. hCS has also apatite formation ability for reducing gap size of microleakage by accumulating hydroxyapatite precipitates at the restoration-tooth interface. Therefore, novel composite resin containing hCS is promising bioactive resin because of its clinically acceptable physiochemical properties, antibacterial properties, and self-sealing potential for prevention of microleakage for longer usage of restorations.

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水合硅酸钙合成的新型抗菌和磷灰石形成恢复性复合树脂。
背景:白硅酸盐水泥是一种硅酸钙材料。它具有抗菌性能和生物相容性。此外,已知硅酸钙基材料会释放钙离子并形成磷灰石。本研究的目的是开发一种具有抗菌和磷灰石形成特性的新型生物活性修复树脂复合材料,通过掺入来自白色硅酸盐水泥的水合硅酸钙(hCS)来预防牙齿和修复材料界面的龋齿。方法:制备30 wt%的光固化树脂基体和70 wt%的填充剂,分别以0、17.5、35.0、52.5 wt%的hCS填充剂与硅化玻璃粉混合制备实验复合树脂。测试了固化深度、抗弯强度、吸水性、溶解度和抗菌效果。分别在人工唾液溶液中浸泡15、30、60、90天后,用ICP-MS分析离子浓度,用SEM-EDS、拉曼光谱和XRD分析实验样品的磷灰石形成情况。结果:各实验组均表现出临床可接受的修复深度和抗弯强度。随着hCS的加入,复合树脂的吸水性、溶解度、释放的Ca、Si离子均有所增加。结论:含hCS填料的复合树脂具有较好的抗菌效果。hCS还具有形成磷灰石的能力,通过在修复体-牙齿界面积聚羟基磷灰石沉淀来减小微漏间隙尺寸。因此,含hCS的新型复合树脂具有临床可接受的理化性能、抗菌性能和防止微渗漏的自密封潜力,是一种很有前景的生物活性树脂。
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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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