Profile of psychotropic agents used in autism spectrum disorder according to comorbidities in Turkey: A 4-year evaluation.

IF 2.1 3区医学 Q3 PHARMACOLOGY & PHARMACY International Clinical Psychopharmacology Pub Date : 2023-07-01 DOI:10.1097/YIC.0000000000000456

Yurdum Karabacak, Sureyya Barun, İsmail Mert Vural, Elif Vural, Elvan Iseri, Aybeniz Civan Kahve, Esra Şafak Yilmaz, Fatma Isli, Sena Turkes, Enes Ezber, Gokcen Paykal

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Abstract

It is known that the use of psychotropic pharmaceuticals is common in comorbidities seen in autism spectrum disorder (ASD). We have very limited knowledge about which psychotropic drugs are prescribed when comorbidities are diagnosed in patients with ASD. It is aimed to determine the profile of psychotropic agents in patients diagnosed with ASD associated with comorbidities between the ages of 0-24 in Turkey over 4 years. Data belonging to ASD in Prescription Information System (PIS) was obtained from the 'Turkish Medicines and Medical Devices Agency'. A total of 34 066 prescriptions including 45 624 psychotropic drugs were analyzed. A total of psychotropic drugs prescribed for patients with ASD was 75.4%. The following psychotropic drugs were prescribed for the patients with ASD and its comorbidities; risperidone (28.6%), aripiprazole (13.7%), and valproic acid (11.3%) are the most preferred psychotropics. The percentage of pharmaceuticals containing psychotropic active substances in prescriptions with ASD and its comorbidities is 7.5%. This study is the first research in which psychotropics used in ASD were evaluated over a wide period and nationwide. Antipsychotics were most commonly prescribed with the diagnosis of ASD. In the presence of ASD and its comorbidities, risperidone was most frequently prescribed.

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根据土耳其的合并症，用于自闭症谱系障碍的精神药物概况:一项为期4年的评估。

众所周知，在自闭症谱系障碍(ASD)的合并症中，精神药物的使用是常见的。当ASD患者被诊断出合并症时，我们对开哪种精神药物的了解非常有限。该研究旨在确定土耳其0-24岁之间诊断为ASD并伴有合并症的患者的精神药物使用情况。处方信息系统(PIS)中属于ASD的数据来自“土耳其药品和医疗器械管理局”。共分析处方34 066张，其中精神类药物45 624种。ASD患者服用精神药物的比例为75.4%。对ASD及其合并症患者使用以下精神药物:利培酮(28.6%)、阿立哌唑(13.7%)和丙戊酸(11.3%)是最受欢迎的精神药物。在自闭症谱系障碍及其合并症的处方中，含有精神药物活性物质的药物占7.5%。这项研究是第一个在全国范围内对ASD中使用的精神药物进行广泛评估的研究。抗精神病药物是ASD诊断时最常见的处方。在存在ASD及其合并症的情况下，利培酮是最常用的处方。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Clinical Psychopharmacology 医学-精神病学

CiteScore

4.40

自引率

23.10%

发文量

审稿时长

>12 weeks

期刊介绍： International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.