Prevention of congenital Chagas disease by screening of mothers and monitoring of serological tests of neonates: the seven years' experience.

Q2 Medicine Infezioni in Medicina Pub Date : 2023-01-01 DOI:10.53854/liim-3102-13
Annibale Raglio, Libera Clemente, Davide Guarneri, Marco Arosio, Marzia Maino, Luisa Patanè, Marco Cavallini, Paola Rodari, Giovanna Mangili, Claudio Farina
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引用次数: 2

Abstract

Approximately 14000 immigrants coming from the Cochabamba area of Bolivia, with an increased risk of congenital Chagas Disease (CD), are currently living in Bergamo, Italy. According to the World Health Organization (WHO) recommendation (2011), prevention of congenital CD involves testing all pregnant women at risk of infection and performing follow-up of their newborns. In our study, all pregnant women of Latin American origin were tested for the presence of Trypanosoma cruzi antibodies and children, born to mothers found to be positive, were followed up after delivery. T. cruzi antibodies were detected using a chemiluminescence immunoassay. The test was also performed on siblings and fathers of children with CD, and women of childbearing age to prevent the congenital infection, as proposed by 2011 WHO recommendation. In the study period 1105 patients were tested for CD, using a serological test: 934 (85%) were females and 171 (15%) were males. Of the 62 newborns, from mothers who tested positive, 28 were females and 34 were males. The number of positive adults and siblings identified was 148 (14%). Among the adults and siblings born between 1991 and 2011 only 3 (2%) of females tested positive to serological test. All neonates, with the exception of one, were classified as non-infected according to the follow-up of index value of CD serology. This study confirms the usefulness of serological tests and of their index value as follow-up. The difference of positivity rate for CD antibodies between people born before and after 1990 should be further investigated to generate information that potentially improve the prevention and control of CD.

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通过筛查母亲和监测新生儿血清学试验预防先天性恰加斯病:七年经验。
来自玻利维亚科恰班巴地区的大约14000名移民目前居住在意大利贝加莫,他们患先天性恰加斯病的风险增加。根据世界卫生组织(世卫组织)的建议(2011年),预防先天性乳糜泻涉及对所有有感染风险的孕妇进行检测,并对其新生儿进行随访。在我们的研究中,所有拉丁美洲的孕妇都检测了克氏锥虫抗体的存在,母亲所生的孩子被发现呈阳性,并在分娩后随访。采用化学发光免疫分析法检测克氏体抗体。根据2011年世卫组织的建议,还对患有乳糜泻儿童的兄弟姐妹和父亲以及育龄妇女进行了该测试,以预防先天性感染。在研究期间,使用血清学测试对1105例患者进行了乳糜泻检测:934例(85%)为女性,171例(15%)为男性。在检测呈阳性的母亲所生的62名新生儿中,28名是女性,34名是男性。成人和兄弟姐妹确诊阳性人数为148人(14%)。在1991年至2011年间出生的成年人和兄弟姐妹中,只有3名(2%)女性血清学检测呈阳性。根据CD血清学指标随访,除1例外,其余新生儿均为未感染。本研究证实了血清学测试的有效性及其作为随访的指标值。应进一步调查1990年前后出生的人乳糜泻抗体阳性率的差异,以提供可能改善乳糜泻预防和控制的信息。
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来源期刊
Infezioni in Medicina
Infezioni in Medicina Medicine-Infectious Diseases
CiteScore
8.40
自引率
0.00%
发文量
62
期刊介绍: The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.
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