Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’

IF 5.3 3区 医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2023-06-01 DOI:10.1016/j.mad.2023.111799
Hugo Cayuela , Jean-Michel Gaillard , Cristina Vieira , Victor Ronget , Jérôme M.W. Gippet , Thamar Conde García , Gabriel A.B. Marais , Jean-François Lemaître
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引用次数: 2

Abstract

In many animal species, including humans, males have shorter lifespan and show faster survival aging than females. This differential increase in mortality between sexes could result from the accumulation of deleterious mutations in the mitochondrial genome of males due to the maternal mode of mtDNA inheritance. To date, empirical evidence supporting the existence of this mechanism – called the Mother Curse hypothesis – remains largely limited to a few study cases in humans and Drosophila. In this study, we tested whether the Mother Curse hypothesis accounts for sex differences in lifespan and aging rate across 128 populations of mammals (60 and 68 populations studied in wild and captive conditions, respectively) encompassing 104 species. We found that adult lifespan decreases with increasing mtDNA neutral substitution rate in both sexes in a similar way in the wild – but not in captivity. Moreover, the aging rate marginally increased with neutral substitution rate in males and females in the wild. Overall, these results indicate that the Mother Curse hypothesis is not supported across mammals. We further discuss the implication of these findings for our understanding of the evolution of sex differences in mortality and aging.

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哺乳动物成年寿命和衰老率的性别差异:对“母亲诅咒假说”的检验
在包括人类在内的许多动物物种中,雄性的寿命比雌性短,并且表现出更快的生存衰老。两性之间死亡率的差异增加可能是由于母体mtDNA遗传模式导致雄性线粒体基因组中有害突变的积累。迄今为止,支持这种机制存在的经验证据——被称为“母亲诅咒假说”——仍然主要局限于人类和果蝇的一些研究案例。在这项研究中,我们测试了母亲诅咒假说是否能解释包含104种动物的128个哺乳动物种群(分别在野生和圈养条件下研究了60个种群和68个种群)的寿命和衰老率的性别差异。我们发现,在野生环境中,随着mtDNA中性替代率的增加,雄性和雌性的成年寿命都会缩短,但在圈养环境中则不然。此外,野生雄性和雌性的衰老率略有增加,中性替代率。总的来说,这些结果表明,母亲诅咒假说在哺乳动物中并不得到支持。我们进一步讨论了这些发现对我们理解死亡率和衰老的性别差异进化的意义。
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来源期刊
CiteScore
11.10
自引率
1.90%
发文量
79
审稿时长
32 days
期刊介绍: Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.
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