Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways.

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY Acta Pharmaceutica Pub Date : 2022-12-01 DOI:10.2478/acph-2022-0038

Li Yu, Jianying Li

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Abstract

Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The current research aimed to evaluate the antiasthmatic effects of punicalagin in an ovalbumin (OVA)-induced experimental model of asthma in female BALB/c mice. Treatment group animals received punicalagin (12.5, 25 or 50 mg kg^-1 body mass) per day for 21 days from day 1 of OVA injection. Dexamethasone (DEX) was administered to a separate group of mice, as the standard drug control. Inflammatory cell infiltration into the broncho-alveolar lavage fluid (BALF) was substantially decreased in punicalagin-treated mice. Punicalagin reduced Th2-derived cytokines and OVA-specific IgE levels. The IL-4/STAT6 and Notch/GATA3 signalling pathways were regulated on punicalagin administration. The data obtained illustrate the potency of punicalagin as an anti-asthmatic drug. Conclusively, the study's observations suggest the potential therapeutic efficiency of punicalagin in allergic asthma.

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Punicalagin通过调节il -4 /IL-4Rα/STAT6和Notch- GATA3通路减轻过敏性气道炎症。

过敏性哮喘是一种病因复杂的气道炎症性疾病。石榴苷是石榴中的一种主要多酚，据报道具有多种生物学特性，包括抗氧化和抗增殖作用。本研究旨在通过卵清蛋白(OVA)诱导的雌性BALB/c小鼠哮喘实验模型，评价punicalagin的平喘作用。治疗组动物从注射OVA第1天开始，每天分别给予12.5、25或50 mg kg-1体重的槟榔苷，连续注射21天。地塞米松(Dexamethasone, DEX)给予另一组小鼠，作为标准药物对照。针刺治疗小鼠的支气管肺泡灌洗液(BALF)炎症细胞浸润明显减少。Punicalagin降低th2来源的细胞因子和ova特异性IgE水平。IL-4/STAT6和Notch/GATA3信号通路在给药后受到调控。所获得的数据说明了槟榔苷作为一种抗哮喘药物的效力。总之，本研究的观察结果表明，punicalagin对过敏性哮喘具有潜在的治疗效果。

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来源期刊

Acta Pharmaceutica PHARMACOLOGY & PHARMACY-

CiteScore

5.20

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： AP is an international, multidisciplinary journal devoted to pharmaceutical and allied sciences and contains articles predominantly on core biomedical and health subjects. The aim of AP is to increase the impact of pharmaceutical research in academia, industry and laboratories. With strong emphasis on quality and originality, AP publishes reports from the discovery of a drug up to clinical practice. Topics covered are: analytics, biochemistry, biopharmaceutics, biotechnology, cell biology, cell cultures, clinical pharmacy, drug design, drug delivery, drug disposition, drug stability, gene technology, medicine (including diagnostics and therapy), medicinal chemistry, metabolism, molecular modeling, pharmacology (clinical and animal), peptide and protein chemistry, pharmacognosy, pharmacoepidemiology, pharmacoeconomics, pharmacodynamics and pharmacokinetics, protein design, radiopharmaceuticals, and toxicology.