Effects of Stimulus Luminance, Stimulus Color and Intra-Stimulus Color Contrast on Visual Field Mapping in Neurologically Impaired Adults Using Flicker Pupil Perimetry.

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2023-01-01 DOI:10.2147/EB.S409905
Brendan L Portengen, Giorgio L Porro, Douwe Bergsma, Evert J Veldman, Saskia M Imhof, Marnix Naber
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Abstract

Purpose: We improve pupillary responses and diagnostic performance of flicker pupil perimetry through alterations in global and local color contrast and luminance contrast in adult patients suffering from visual field defects due to cerebral visual impairment (CVI).

Methods: Two experiments were conducted on patients with CVI (Experiment 1: 19 subjects, age M and SD 57.9 ± 14.0; Experiment 2: 16 subjects, age M and SD 57.3 ± 14.7) suffering from absolute homonymous visual field (VF) defects. We altered global color contrast (stimuli consisted of white, yellow, cyan and yellow-equiluminant-to-cyan colored wedges) in Experiment 1, and we manipulated luminance and local color contrast with bright and dark yellow and multicolor wedges in a 2-by-2 design in Experiment 2. Stimuli consecutively flickered across 44 stimulus locations within the inner 60 degrees of the VF and were offset to a contrasting (opponency colored) dark background. Pupil perimetry results were compared to standard automated perimetry (SAP) to assess diagnostic accuracy.

Results: A bright stimulus with global color contrast using yellow (p= 0.009) or white (p= 0.006) evoked strongest pupillary responses as opposed to stimuli containing local color contrast and lower brightness. Diagnostic accuracy, however, was similar across global color contrast conditions in Experiment 1 (p= 0.27) and decreased when local color contrast and less luminance contrast was introduced in Experiment 2 (p= 0.02). The bright yellow condition resulted in highest performance (AUC M = 0.85 ± 0.10, Mdn = 0.85).

Conclusion: Pupillary responses and pupil perimetry's diagnostic accuracy both benefit from high luminance contrast and global but not local color contrast.

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刺激亮度、刺激颜色和刺激内颜色对比对使用闪烁瞳孔周边测量的神经损伤成人视野映射的影响。
目的:通过改变脑性视觉障碍(CVI)所致视野缺损的成人患者的整体和局部颜色对比和亮度对比,改善闪烁瞳孔周边测量的瞳孔反应和诊断性能。方法:对CVI患者进行2项实验(实验1:19例,年龄M, SD 57.9±14.0;实验2:16例患者,年龄M, SD(57.3±14.7),患有完全同位视野缺损。在实验1中,我们改变了整体颜色对比度(刺激由白色、黄色、青色和黄-蓝等色楔组成),在实验2中,我们用2 × 2设计的明黄色和暗黄色和多色楔来操纵亮度和局部颜色对比度。在视场内60度的44个刺激位置上,刺激连续闪烁,并被抵消到一个对比色的暗背景上。瞳孔周边检查结果与标准自动周边检查(SAP)进行比较,以评估诊断准确性。结果:与含有局部颜色对比和较低亮度的刺激相比,黄色(p= 0.009)或白色(p= 0.006)具有全局颜色对比的明亮刺激引起了最强的瞳孔反应。然而,在实验1中,诊断准确性在全局色彩对比条件下是相似的(p= 0.27),而在实验2中,当引入局部色彩对比和较低亮度对比时,诊断准确性下降(p= 0.02)。在亮黄色条件下表现最佳(AUC M = 0.85±0.10,Mdn = 0.85)。结论:高亮度对比和全局色彩对比有利于瞳孔反应和瞳孔周边检查的诊断准确性。
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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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