Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report.

IF 2.3 4区医学 Q3 ONCOLOGY Pathology & Oncology Research Pub Date : 2023-01-01 DOI:10.3389/pore.2023.1611151

Wen Han, Bei Wang, Xiang Yong, Yi Zhang, Mingyu Shao, Chun Wang

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Abstract

Objective: Indolent T-lymphoblastic proliferation (iT-LBP) is a non-neoplastic disease with an indolent clinical course, manifesting as hyperplasia of immature extrathymic T-lymphoblastic cells. Isolated iT-LBP has been observed, but the majority of iT-LBP cases has been seen in conjunction with other diseases. iT-LBP is easily misdiagnosed as T-lymphoblastic lymphoma/leukemia, and understanding the disease of indolent T-lymphoblastic proliferation may prevent misdiagnosis and missed diagnosis in pathological diagnosis. Case presentation: We report a case morphology, immunophenotypic, and molecular features of iT-LBP combined with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma and review relevant literature. Conclusion: iT-LBP combined with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma is relatively rare and should always be considered as a differential diagnosis of T-lymphoblastic lymphoma and scirrhous hepatocellular carcinoma as the two disorders show highly similar clinical features.

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结直肠癌后并发纤维板层性肝细胞癌的惰性t淋巴细胞增殖1例。

目的:惰性t淋巴母细胞增生(idolent t - blastic proliferation, iT-LBP)是一种临床过程为惰性的非肿瘤性疾病，表现为未成熟胸腺外t淋巴母细胞增生。已观察到孤立的iT-LBP，但大多数iT-LBP病例与其他疾病合并。iT-LBP易误诊为t淋巴母细胞淋巴瘤/白血病，了解这种惰性t淋巴母细胞增殖的疾病可防止病理诊断中的误诊和漏诊。病例介绍:我们报告1例结直肠癌后发生的iT-LBP合并纤维板层性肝细胞癌的形态学、免疫表型和分子特征，并复习相关文献。结论:iT-LBP合并结直肠腺癌后发生的纤维板层性肝细胞癌较为罕见，临床特征高度相似，应作为t淋巴母细胞淋巴瘤和黏性肝细胞癌的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology & Oncology Research 医学-病理学

CiteScore

6.30

自引率

0.00%

发文量

134

审稿时长

4-8 weeks

期刊介绍： Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.