Effect of Bitter-leaf (Vernonia amygdalina) Flavored Non-alcoholic Wheat Beer (NAWB) on, Insulin and GLUT-2 expression in Pancreas of High fat diet/Streptozotocin (HFD/STZ) Induced Diabetic Wistar Rats.

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM Journal of Diabetes and Metabolic Disorders Pub Date : 2023-03-25 eCollection Date: 2023-06-01 DOI:10.1007/s40200-023-01216-2

Gbenga P Akerele, Bukola C Adedayo, Ganiyu Oboh, Opeyemi B Ogunsuyi

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Abstract

Purpose: In the management of type 2 diabetes (T2D), dietary intervention has been proposed to be highly effective. This study, therefore, investigated the effect of bitter leaf-flavored non-alcoholic wheat beer (NAWB) on insulin secretion and GLUT-2 expression in the pancreas of STZ-induced diabetic rats.

Methods: In this study, the rats received a single intraperitoneal injection (i.p.) of STZ (35 mg/kg) after being fed a high-fat diet for 14 days to induce T2D. The rats were treated with bitter leaf flavored NAWB samples (100%HP- Hops only, 100%BL-Bitter leaf only, 75,25BL- 75% Hops, 25% Bitter Leaf, 50:50BL- 50% Hops:50% Bitter Leaf, and 25:75BL-25%Hops:75% Bitter Leaf) and Acarbose for 14 days. The superoxide dismutase, catalase, and glutathione peroxidase activity were also determined.

Results: The results from this study showed a correlation between GLUT-2 and Insulin expression. There was an upregulation of Insulin as GLUT-2 expression was upregulated. Furthermore, the treated groups showed better antioxidant activity when compared with the diabetic control.

Conclusion: Bitter leaf-flavored NAWB might thus be a good dietary intervention for type 2 diabetics.

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苦叶风味无酒精小麦啤酒（NAWB）对高脂饮食/链脲佐菌素（HFD/STZ）诱导的糖尿病Wistar大鼠胰腺胰岛素和GLUT-2表达的影响。

目的：在2型糖尿病（T2D）的治疗中，饮食干预被认为是非常有效的。因此，本研究探讨了苦叶风味无酒精小麦啤酒（NAWB）对STZ诱导的糖尿病大鼠胰腺胰岛素分泌和GLUT-2表达的影响。方法：在本研究中，大鼠在喂食高脂饮食14天后，接受单次腹膜内注射（i.p.）STZ（35mg/kg）以诱导T2D。大鼠用苦叶味NAWB样品（仅100%HP啤酒花，仅100%BL苦叶，75,25BL-75%啤酒花，25%苦叶，50:50BL-50%啤酒花：50%苦叶，25:75BL-25%啤酒花：75%苦叶）和Acarbose处理14天。还测定了超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性。结果：本研究结果显示GLUT-2与胰岛素表达之间存在相关性。随着GLUT-2表达的上调，胰岛素也出现了上调。此外，与糖尿病对照组相比，治疗组表现出更好的抗氧化活性。结论：苦叶味NAWB对2型糖尿病患者有较好的膳食干预作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.