Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer

IF 12.1 1区医学 Q1 ONCOLOGY Seminars in cancer biology Pub Date : 2023-08-01 DOI:10.1016/j.semcancer.2023.05.007

Rohit Sarkar , Zhihong Xu , Chamini J. Perera , Minoti V. Apte

{"title":"Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer","authors":"Rohit Sarkar , Zhihong Xu , Chamini J. Perera , Minoti V. Apte","doi":"10.1016/j.semcancer.2023.05.007","DOIUrl":null,"url":null,"abstract":"<div><p>Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that is characterised by a prominent collagenous stromal reaction/desmoplasia surrounding tumour cells. Pancreatic stellate cells (PSCs) are responsible for the production of this stroma and have been shown to facilitate PDAC progression. Recently, extracellular vesicles (EVs), in particular, small extracellular vesicles (exosomes) have been a topic of interest in the field of cancer research for their emerging roles in cancer progression and diagnosis. EVs act as a form of intercellular communication by carrying their molecular cargo from one cell to another, regulating functions of the recipient cells. Although the knowledge of the bi-directional interactions between the PSCs and cancer cells that promote disease progression has advanced significantly over the past decade, studies on PSC-derived EVs in PDAC are currently rather limited. This review provides an overview of PDAC, pancreatic stellate cells and their interactions with cancer cells, as well as the currently known role of extracellular vesicles derived from PSCs in PDAC progression.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":null,"pages":null},"PeriodicalIF":12.1000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in cancer biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044579X23000810","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 3

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that is characterised by a prominent collagenous stromal reaction/desmoplasia surrounding tumour cells. Pancreatic stellate cells (PSCs) are responsible for the production of this stroma and have been shown to facilitate PDAC progression. Recently, extracellular vesicles (EVs), in particular, small extracellular vesicles (exosomes) have been a topic of interest in the field of cancer research for their emerging roles in cancer progression and diagnosis. EVs act as a form of intercellular communication by carrying their molecular cargo from one cell to another, regulating functions of the recipient cells. Although the knowledge of the bi-directional interactions between the PSCs and cancer cells that promote disease progression has advanced significantly over the past decade, studies on PSC-derived EVs in PDAC are currently rather limited. This review provides an overview of PDAC, pancreatic stellate cells and their interactions with cancer cells, as well as the currently known role of extracellular vesicles derived from PSCs in PDAC progression.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

胰腺星状细胞来源的细胞外囊泡在胰腺癌中的新作用

胰腺导管腺癌（PDAC）是一种高度侵袭性的癌症，其特征是肿瘤细胞周围明显的胶原基质反应/结缔组织增生。胰腺星状细胞（PSCs）负责产生这种基质，并已被证明促进PDAC的进展。近年来，细胞外囊泡（EVs），特别是小细胞外囊袋（外泌体），因其在癌症进展和诊断中的新作用而成为癌症研究领域的一个感兴趣的话题。EVs通过将其分子货物从一个细胞携带到另一个细胞，调节受体细胞的功能，起到细胞间通信的作用。尽管在过去十年中，对促进疾病进展的PSC和癌症细胞之间的双向相互作用的了解取得了显著进展，但目前对PDAC中PSC衍生EVs的研究相当有限。这篇综述概述了PDAC、胰腺星状细胞及其与癌症细胞的相互作用，以及目前已知的来源于PSCs的细胞外囊泡在PDAC进展中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.