The evaluation of serum brain-derived neurotrophic factor levels in pregnant women with hyperemesis gravidarum.

IF 1.2 4区医学 Q3 OBSTETRICS & GYNECOLOGY Ginekologia polska Pub Date : 2023-06-12 DOI:10.5603/GP.a2023.0049

Busra Demir Cendek, Betul Tokgoz Cakir, Rahime Bedir Fındık, Mujde Can Ibanoglu, Melahat Yildirim, Huseyin Tugrul Celik, Ayse Filiz Yavuz

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Abstract

Objectives: The aim of this study was to investigate the relationship between levels of brain-derived neurotrophic factor (BDNF), which is considered a cause of conditions such as depression and eating disorders, and hyperemesis gravidarum (HG).

Material and methods: This study was conducted as a prospective study at Ankara Ataturk Training and Research Hospital in the Department of Obstetrics and Gynecology. The study included 73 pregnant women with singleton pregnancies (32 pregnant women with HG and 41 pregnant women without hyperemesis). Serum BDNF levels were compared between the two groups.

Results: The mean age of the study group was 27.3 ± 3.5 years and the body mass index (BMI) was 22.4 ± 2.7 kg/m². There is no statistically significant difference between the study group and the control group in terms of demographic data (p > 0.05). The pregnant women with HG were found to have significantly higher serum BDNF levels compared to the control group (349.1 ± 94.6 pg/mL vs 292. 3± 86.01, p = 0.009) CONCLUSIONS: Serum BDNF levels that are low in psychiatric disorders such as depression or anxiety were found as high in pregnant women with HG.

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妊娠剧吐孕妇血清脑源性神经营养因子水平的评价。

目的:本研究的目的是研究脑源性神经营养因子(BDNF)水平与妊娠剧吐(HG)之间的关系，BDNF被认为是抑郁症和饮食失调等疾病的原因。材料和方法:本研究是在安卡拉阿塔图尔克培训和研究医院妇产科进行的一项前瞻性研究。该研究包括73名单胎妊娠孕妇(32名HG孕妇和41名无呕吐孕妇)。比较两组患者血清BDNF水平。结果:研究组平均年龄27.3±3.5岁，体重指数(BMI)为22.4±2.7 kg/m²。研究组与对照组人口学资料比较，差异无统计学意义(p > 0.05)。HG孕妇血清BDNF水平明显高于对照组(349.1±94.6 pg/mL vs 292)。(3±86.01,p = 0.009)结论:抑郁、焦虑等精神障碍患者血清BDNF水平较低，而HG孕妇血清BDNF水平较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ginekologia polska OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

15.40%

发文量

317

审稿时长

4-8 weeks

期刊介绍： Ginekologia Polska’ is a monthly medical journal published in Polish and English language. ‘Ginekologia Polska’ will accept submissions relating to any aspect of gynaecology, obstetrics and areas directly related. ‘Ginekologia Polska’ publishes original contributions, comparative works, case studies, letters to the editor and many other categories of articles.