The core outcomes for open lower limb fracture study.

IF 4.7 2区 医学 Q2 CELL & TISSUE ENGINEERING Bone & Joint Research Pub Date : 2023-06-01 DOI:10.1302/2046-3758.126.BJR-2022-0280.R1
Alexander L Aquilina, Harry Claireaux, Christian O Aquilina, Elizabeth Tutton, Ray Fitzpatrick, Matthew L Costa, Xavier L Griffin
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引用次数: 1

Abstract

Aims: A core outcome set for adult, open lower limb fracture has been established consisting of 'Walking, gait and mobility', 'Being able to return to life roles', 'Pain or discomfort', and 'Quality of life'. This study aims to identify which outcome measurement instruments (OMIs) should be recommended to measure each core outcome.

Methods: A systematic review and quality assessment were conducted to identify existing instruments with evidence of good measurement properties in the open lower limb fracture population for each core outcome. Additionally, shortlisting criteria were developed to identify suitable instruments not validated in the target population. Candidate instruments were presented, discussed, and voted on at a consensus meeting of key stakeholders.

Results: The Wales Lower Limb Trauma Recovery scale was identified, demonstrating validation evidence in the target population. In addition, ten candidate OMIs met the shortlisting criteria. Six patients, eight healthcare professionals, and 11 research methodologists attended the consensus meeting. Consensus was achieved for the EuroQol five-dimension five-level questionnaire (EQ-5D-5L) and the Lower Extremity Functional Scale (LEFS) to measure 'Quality of life' and 'Walking, gait and mobility' in future research trials, audit, and clinical assessment, respectively. No instrument met consensus criteria to measure 'Being able to return to life roles' and 'Pain or discomfort'. However, the EQ-5D-5L was found to demonstrate good face validity and could also be used pragmatically to measure these two outcomes, accepting limitations in sensitivity.

Conclusion: This study recommends the LEFS and EQ-5D-5L to measure the core outcome set for adult open lower limb fracture.

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开放性下肢骨折研究的核心结局。
目的:建立了成人开放性下肢骨折的核心结果,包括“行走、步态和活动能力”、“能够恢复生活角色”、“疼痛或不适”和“生活质量”。本研究旨在确定应推荐哪些结果测量工具(OMIs)来测量每个核心结果。方法:进行系统的回顾和质量评估,以确定现有的仪器在开放性下肢骨折人群的每个核心结果中具有良好的测量性能。此外,还制定了候选名单标准,以确定在目标人群中未得到验证的合适工具。在关键利益相关者的协商一致会议上,提出、讨论和表决了候选文书。结果:确定了威尔士下肢创伤恢复量表,在目标人群中展示了验证证据。此外,10个候选omi符合入围标准。6名患者、8名医疗保健专业人员和11名研究方法学家参加了共识会议。EuroQol五维五级问卷(EQ-5D-5L)和下肢功能量表(LEFS)分别在未来的研究试验、审计和临床评估中测量“生活质量”和“行走、步态和活动能力”,达成了共识。没有一种工具符合衡量“能否回归生活角色”和“疼痛或不适”的共识标准。然而,EQ-5D-5L被发现表现出良好的面部效度,也可以实用地用于测量这两个结果,接受灵敏度的限制。结论:本研究推荐使用LEFS和EQ-5D-5L来测量成人开放性下肢骨折的核心预后集。
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来源期刊
Bone & Joint Research
Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS
CiteScore
7.40
自引率
23.90%
发文量
156
审稿时长
12 weeks
期刊介绍: The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.
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