Reduction of estimated glomerular filtration rate after COVID-19-associated acute kidney injury.

IF 1.3 Q3 UROLOGY & NEPHROLOGY Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2023-10-01 DOI:10.1590/2175-8239-JBN-2022-0179en

Gabrielle Accioly Omena Bento, Vivian Larissa Tenório Leite, Rodrigo Peixoto Campos, Flora Braga Vaz, Elizabeth De Francesco Daher, Daniella Bezerra Duarte

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Abstract

Introduction: Acute Kidney Injury (AKI), a frequent manifestation in COVID-19, can compromise kidney function in the long term. We evaluated renal function after hospital discharge of patients who developed AKI associated with COVID-19.

Methods: This is an ambidirectional cohort. eGFR and microalbuminuria were reassessed after hospital discharge (T1) in patients who developed AKI due to COVID-19, comparing the values with hospitalization data (T0). P < 0.05 was considered statistically significant.

Results: After an average of 16.3 ± 3.5 months, 20 patients were reassessed. There was a median reduction of 11.5 (IQR: -21; -2.1) mL/min/1.73m2 per year in eGFR. Forty-five percent of patients had CKD at T1, were older, and had been hospitalized longer; this correlated negatively with eGFR at T1. Microalbuminuria was positively correlated with CRP at T0 and with a drop in eGFR, as well as eGFR at admission with eGFR at T1.

Conclusion: There was a significant reduction in eGFR after AKI due to COVID-19, being associated with age, length of hospital stay, CRP, and need for hemodialysis.

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COVID-19 相关急性肾损伤后估计肾小球滤过率降低。

简介急性肾损伤（AKI）是COVID-19的一种常见表现，会长期损害肾功能。我们对与 COVID-19 相关的急性肾损伤患者出院后的肾功能进行了评估：因 COVID-19 引起 AKI 的患者出院后（T1），我们对其 eGFR 和微量白蛋白尿进行了重新评估，并与住院数据（T0）进行了比较。P<0.05为差异有统计学意义：平均 16.3 ± 3.5 个月后，对 20 名患者进行了重新评估。eGFR 中位数每年下降 11.5（IQR：-21；-2.1）毫升/分钟/1.73 平方米。45%的患者在第一阶段患有慢性肾脏病，年龄较大，住院时间较长；这与第一阶段的 eGFR 呈负相关。微量白蛋白尿与T0时的CRP和eGFR下降呈正相关，入院时的eGFR与T1时的eGFR也呈正相关：结论：COVID-19导致AKI后eGFR明显下降，与年龄、住院时间、CRP和血液透析需求有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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