Hepatic Fat and Macrophages Are Increased in Livers of Diabetic Patients without Non-Alcoholic Fatty Liver Disease.

IF 3.5 4区 医学 Q3 CELL BIOLOGY Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-06-14 DOI:10.1159/000531542
Amber Korn, Cacharel Nadeem, Emma N Bos, Hans W M Niessen, Suat Simsek, Paul A J Krijnen
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引用次数: 0

Abstract

Introduction: Diabetes mellitus (DM), especially type 2, is strongly associated with non-alcoholic fatty liver disease (NAFLD). Recent studies indicate that particularly in DM patients, "simple" liver steatosis can progress into more severe disease. However, little is known about putative hepatic histopathological changes in DM patients without NAFLD. In this study, we therefore analysed fat content and inflammatory cell infiltration in the livers of deceased DM and non-DM patients without NAFLD, and analysed age/sex effects hereon.

Methods: Hepatic fat and inflammatory cells were studied through (immuno)histochemical analysis in liver tissue from 24 DM patients and 66 non-diabetic controls, without histopathological characteristics of NAFLD.

Results: We observed a 2-fold increase in fat percentage/mm2 and a near 5-fold increase in the number of fat-containing cells/mm2 in DM patients compared to non-diabetic controls. Fat content was significantly higher in patients with type 2 DM, but not type 1 DM, compared to non-diabetic controls, while the number of CD68+ cells/mm2 was significantly elevated in both DM groups.

Conclusion: Hepatic fat and number of macrophages are increased in patients with DM without NAFLD, which may reflect a higher risk on development of steatosis and steatohepatitis.

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无非酒精性脂肪肝的糖尿病患者肝脏脂肪和巨噬细胞增加
导言:糖尿病(DM),尤其是 2 型糖尿病,与非酒精性脂肪肝(NAFLD)密切相关。最近的研究表明,特别是在糖尿病患者中,"简单的 "肝脏脂肪变性可发展成更严重的疾病。然而,人们对没有非酒精性脂肪肝的糖尿病患者的肝组织病理学变化知之甚少。因此,在这项研究中,我们分析了已故 DM 患者和非 DM 患者肝脏中的脂肪含量和炎症细胞浸润情况,并分析了年龄/性别对其影响。方法:通过对 24 名 DM 患者和 66 名非糖尿病对照者的肝组织进行(免疫)组织化学分析,研究肝脏脂肪和炎症细胞,这些患者没有非酒精性脂肪肝的组织病理学特征:我们观察到,与非糖尿病对照组相比,DM 患者的脂肪百分比/mm2 增加了 2 倍,含脂肪细胞数量/mm2 增加了近 5 倍。与非糖尿病对照组相比,2 型糖尿病患者的脂肪含量明显较高,而 1 型糖尿病患者的脂肪含量则不高:结论:未患非酒精性脂肪肝的 DM 患者的肝脏脂肪和巨噬细胞数量均有所增加,这可能反映出患者发生脂肪变性和脂肪性肝炎的风险较高。
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来源期刊
Pathobiology
Pathobiology 医学-病理学
CiteScore
8.50
自引率
0.00%
发文量
47
审稿时长
>12 weeks
期刊介绍: ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.
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