Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report.

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY Acta Pharmaceutica Pub Date : 2023-06-01 DOI:10.2478/acph-2023-0011

Simona Sovová, Štefánia Laca Megyesi, Dagmar Mudroňová, Pavol Mudroň, Jarmila Harvanová, Michaela Rendošová, Michal Goga, Ľudmila Tkáčiková, Zuzana Vargová

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Abstract

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)₂]NO₃·H₂O ( AgNam), [Ag₂(HGly)₂]_n(NO₃)_2n (AgGly) (Nam - nicotin-amide, Gly - glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87-5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions -16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions.

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新型潜在银(I)配合物面霜的抗菌活性、质量和稳定性研究及体内病例报告。

以市售的银(I)配合物[Ag(Nam)2]NO3·H2O (AgNam)、[Ag2(HGly)2]n(NO3)2n (AgGly) (Nam - nictin -amide, Gly -甘氨酸)和银(I)磺胺嘧啶(AgSD)为原料，制备药膏(浓度为1%)，考察其抑菌活性、质量和稳定性。采用琼脂孔扩散法和体内实验对其抑菌活性进行了评价。纯银(I)配合物以及所有三种负载AgGly、AgSD和AgNam的测试面霜都显示出抗菌潜力。此外，AgGly和AgNam对金黄色葡萄球菌和枯草芽孢杆菌的抑菌效果优于AgSD。外观方面，所有乳霜样品不透明，无异味，无相分离现象。乳霜可溶于水(0 /w乳液)，具有假塑性行为。乳膏的pH值在4.87 ~ 5.75之间。在-16±1°C的条件下，在一个月的测试期间，商用AgSD乳膏未观察到明显的变化;6±1℃，相对湿度56%;20±1℃，58%相对湿度和40±1℃，75%相对湿度。然而，含有AgGly和AgNam的面霜会根据测试条件改变颜色。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Pharmaceutica PHARMACOLOGY & PHARMACY-

CiteScore

5.20

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： AP is an international, multidisciplinary journal devoted to pharmaceutical and allied sciences and contains articles predominantly on core biomedical and health subjects. The aim of AP is to increase the impact of pharmaceutical research in academia, industry and laboratories. With strong emphasis on quality and originality, AP publishes reports from the discovery of a drug up to clinical practice. Topics covered are: analytics, biochemistry, biopharmaceutics, biotechnology, cell biology, cell cultures, clinical pharmacy, drug design, drug delivery, drug disposition, drug stability, gene technology, medicine (including diagnostics and therapy), medicinal chemistry, metabolism, molecular modeling, pharmacology (clinical and animal), peptide and protein chemistry, pharmacognosy, pharmacoepidemiology, pharmacoeconomics, pharmacodynamics and pharmacokinetics, protein design, radiopharmaceuticals, and toxicology.