[Intestinal pneumatosis developed during the treatment of severe gastrointestinal graft-versus-host disease after cord blood transplantation].

Yuma Kawamura, Nobuaki Fukushima, Tomoki Fujii, Masaya Numata, Makoto Ito, Shiori Morikawa, Miyo Goto, Akio Kohno, Kazutaka Ozeki
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Abstract

A 62-year-old female developed stage4 gastrointestinal graft-versus-host disease (GVHD) on day 109 following an allogeneic cord blood transplant for relapsed refractory angioimmunoblastic T-cell lymphoma. GVHD went into remission 4 weeks after receiving the steroid (mPSL 1 mg/kg), but abdominal bloating started to emerge at the same time. A diagnosis of intestinal pneumatosis was made on day 158 after a CT scan revealed submucosal and serosal pneumatosis in the entire colon, and intestinal pneumatosis was identified as the cause. Fasting and reducing steroid use have helped. the abdominal symptoms, and the pneumatosis disappeared on day 175. No more flare-ups occurred, and the steroid was successfully stopped. After allogeneic transplantation, intestinal pneumatosis is a rather uncommon complications. Its pathogenesis is thought to be influenced by GVHD or steroids. Treatments for the disease may be incompatible with one another, and the response in individual cases needs to be studied in detail.

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[脐带血移植后严重胃肠道移植物抗宿主病治疗期间发生的肠道肺炎]。
一名62岁女性因复发难治性血管免疫母细胞t细胞淋巴瘤接受同种异体脐带血移植术后第109天出现4期胃肠道移植物抗宿主病(GVHD)。GVHD在接受类固醇(mPSL 1mg /kg)治疗4周后进入缓解期,但同时开始出现腹胀。第158天,CT扫描显示整个结肠粘膜下及浆膜性肺肿,诊断为肠性肺肿,病因确定为肠性肺肿。禁食和减少类固醇的使用有所帮助。第175天腹部症状消失,肺气肿消失。不再出现急性发作,类固醇被成功停用。同种异体移植后,肠内肺病是一种比较少见的并发症。其发病机制被认为受GVHD或类固醇的影响。对这种疾病的治疗可能彼此不相容,需要对个别病例的反应进行详细研究。
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