Current development and clinical applications of artificial anal sphincter.

IF 2.9 3区 医学 Q3 ENGINEERING, BIOMEDICAL Expert Review of Medical Devices Pub Date : 2023-07-01 DOI:10.1080/17434440.2023.2219000
Minghui Wang, Yunlong Liu, Qingjun Nong, Hongliu Yu
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Abstract

Introduction: Fecal incontinence is a common chronic disease, which not only brings inconvenience to the lives of patients, but also causes great psychological harm to patients. Artificial anal sphincter is an innovative method that may treat fecal incontinence, and now has been clinically applied.

Areas covered: This article will review recent developments in mechanisms and clinical applications of artificial anal sphincter. The current results of clinical trials show that the implantation of artificial sphincter will cause morphological changes of surrounding tissues, and related biomechanical imbalance will lead to the loss of effectiveness of the device and various complications. In terms of safety, postoperative patients suffer from various complications such as infection, corrosion, tissue ischemia, mechanical failure, and difficulty in emptying. In terms of effectiveness, there is currently no long-term research data to prove that the implanted device can maintain a long-term functional state.

Expert opinion: The key issue for the safety and effectiveness of implantable devices is the biomechanical compatibility of implantable devices was proposed. Based on the superelasticity of shape memory alloy, this article proposes a new type of constant force artificial sphincter device, which provides a new direction for solving the clinical application of artificial anal sphincter.

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人工肛门括约肌的发展现状及临床应用。
导读:大便失禁是一种常见的慢性疾病,不仅给患者的生活带来不便,而且对患者造成很大的心理伤害。人工肛门括约肌是一种治疗大便失禁的创新方法,目前已在临床上得到应用。涉及领域:本文将综述人工肛门括约肌的机制和临床应用的最新进展。目前的临床试验结果表明,人工括约肌的植入会引起周围组织的形态改变,相关的生物力学失衡会导致装置的有效性丧失和各种并发症。在安全性方面,术后患者存在感染、腐蚀、组织缺血、机械故障、排空困难等多种并发症。在有效性方面,目前还没有长期的研究数据证明植入装置能够保持长期的功能状态。专家意见:植入式装置安全性和有效性的关键问题是植入式装置的生物力学相容性。本文基于形状记忆合金的超弹性,提出了一种新型恒力人工括约肌装置,为解决人工肛门括约肌的临床应用提供了新的方向。
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来源期刊
Expert Review of Medical Devices
Expert Review of Medical Devices 医学-工程:生物医学
CiteScore
5.90
自引率
3.20%
发文量
69
审稿时长
6-12 weeks
期刊介绍: The journal serves the device research community by providing a comprehensive body of high-quality information from leading experts, all subject to rigorous peer review. The Expert Review format is specially structured to optimize the value of the information to reader. Comprehensive coverage by each author in a key area of research or clinical practice is augmented by the following sections: Expert commentary - a personal view on the most effective or promising strategies Five-year view - a clear perspective of future prospects within a realistic timescale Key issues - an executive summary cutting to the author''s most critical points In addition to the Review program, each issue also features Medical Device Profiles - objective assessments of specific devices in development or clinical use to help inform clinical practice. There are also Perspectives - overviews highlighting areas of current debate and controversy, together with reports from the conference scene and invited Editorials.
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