Functional (un-)Coupling: Impairment, Compensation, and Future Progression in Alzheimer's Disease.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Clinical EEG and Neuroscience Pub Date : 2023-05-01 DOI:10.1177/15500594211052208
Jochen A Mosbacher, Markus Waser, Heinrich Garn, Stephan Seiler, Carmina Coronel, Peter Dal-Bianco, Thomas Benke, Manfred Deistler, Gerhard Ransmayr, Florian Mayer, Guenter Sanin, Anita Lechner, Helmut K Lackner, Petra Schwingenschuh, Dieter Grossegger, Reinhold Schmidt
{"title":"Functional (un-)Coupling: Impairment, Compensation, and Future Progression in Alzheimer's Disease.","authors":"Jochen A Mosbacher,&nbsp;Markus Waser,&nbsp;Heinrich Garn,&nbsp;Stephan Seiler,&nbsp;Carmina Coronel,&nbsp;Peter Dal-Bianco,&nbsp;Thomas Benke,&nbsp;Manfred Deistler,&nbsp;Gerhard Ransmayr,&nbsp;Florian Mayer,&nbsp;Guenter Sanin,&nbsp;Anita Lechner,&nbsp;Helmut K Lackner,&nbsp;Petra Schwingenschuh,&nbsp;Dieter Grossegger,&nbsp;Reinhold Schmidt","doi":"10.1177/15500594211052208","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Functional (un-)coupling (task-related change of functional connectivity) between different sites of the brain is a mechanism of general importance for cognitive processes. In Alzheimer's disease (AD), prior research identified diminished cortical connectivity as a hallmark of the disease. However, little is known about the relation between the amount of functional (un-)coupling and cognitive performance and decline in AD. <b>Method:</b> Cognitive performance (based on CERAD-Plus scores) and electroencephalogram (EEG)-based functional (un-)coupling measures (connectivity changes from rest to a Face-Name-Encoding task) were assessed in 135 AD patients (age: <i>M</i> = 73.8 years; <i>SD</i> = 9.0). Of these, 68 patients (<i>M</i> = 73.9 years; <i>SD</i> = 8.9) participated in a follow-up assessment of their cognitive performance 1.5 years later. <b>Results:</b> The amounts of functional (un-)coupling in left anterior-posterior and homotopic interhemispheric connections in beta1-band were related to cognitive performance at baseline (β = .340; <i>p</i> < .001; β = .274; <i>P</i> = .001, respectively). For both markers, a higher amount of functional coupling was associated with better cognitive performance. Both markers also were significant predictors for cognitive decline. However, while patients with greater functional coupling in left anterior-posterior connections declined less in cognitive performance (β = .329; <i>P</i> = .035) those with greater functional coupling in interhemispheric connections declined more (β = -.402; <i>P</i> = .010). <b>Conclusion:</b> These findings suggest an important role of functional coupling mechanisms in left anterior-posterior and interhemispheric connections in AD. Especially the complex relationship with cognitive decline in AD patients might be an interesting aspect for future studies.</p>","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical EEG and Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15500594211052208","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Functional (un-)coupling (task-related change of functional connectivity) between different sites of the brain is a mechanism of general importance for cognitive processes. In Alzheimer's disease (AD), prior research identified diminished cortical connectivity as a hallmark of the disease. However, little is known about the relation between the amount of functional (un-)coupling and cognitive performance and decline in AD. Method: Cognitive performance (based on CERAD-Plus scores) and electroencephalogram (EEG)-based functional (un-)coupling measures (connectivity changes from rest to a Face-Name-Encoding task) were assessed in 135 AD patients (age: M = 73.8 years; SD = 9.0). Of these, 68 patients (M = 73.9 years; SD = 8.9) participated in a follow-up assessment of their cognitive performance 1.5 years later. Results: The amounts of functional (un-)coupling in left anterior-posterior and homotopic interhemispheric connections in beta1-band were related to cognitive performance at baseline (β = .340; p < .001; β = .274; P = .001, respectively). For both markers, a higher amount of functional coupling was associated with better cognitive performance. Both markers also were significant predictors for cognitive decline. However, while patients with greater functional coupling in left anterior-posterior connections declined less in cognitive performance (β = .329; P = .035) those with greater functional coupling in interhemispheric connections declined more (β = -.402; P = .010). Conclusion: These findings suggest an important role of functional coupling mechanisms in left anterior-posterior and interhemispheric connections in AD. Especially the complex relationship with cognitive decline in AD patients might be an interesting aspect for future studies.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
功能(非)耦合:阿尔茨海默病的损伤、补偿和未来进展。
背景:大脑不同部位之间的功能(非)耦合(功能连接的任务相关变化)是认知过程中普遍重要的机制。在阿尔茨海默病(AD)中,先前的研究确定皮质连通性减弱是该疾病的标志。然而,关于功能(非)偶联量与认知表现和AD下降之间的关系知之甚少。方法:评估135例AD患者的认知表现(基于CERAD-Plus评分)和基于脑电图(EEG)的功能(非)耦合测量(从休息到面孔-名称编码任务的连接变化)。sd = 9.0)。其中,68例患者(M = 73.9岁;SD = 8.9)在1.5年后对他们的认知表现进行随访评估。结果:β - 1带左前后半球连接和同位半球连接的功能性(非)偶联量与基线时的认知表现相关(β = 0.340;p =。001年,分别)。对于这两种标记,更高数量的功能耦合与更好的认知表现相关。这两项指标也是认知能力下降的重要预测指标。然而,当左前后连接功能耦合较大的患者认知能力下降较少(β = .329;P = 0.035),脑间连接功能耦合较大的患者脑功能衰退更严重(β = - 0.402;p = .010)。结论:这些发现提示AD左前后半球连接的功能耦合机制在AD左前后半球连接中起重要作用。特别是与AD患者认知能力下降的复杂关系可能是未来研究的一个有趣方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
期刊最新文献
Ikelos-RWA. Validation of an Automatic Tool to Quantify REM Sleep Without Atonia. Age-dependent Electroencephalogram Characteristics During Different Levels of Anesthetic Depth. The Clinical Utility of Finding Unexpected Subclinical Spikes Detected by High-Density EEG During Neurodiagnostic Investigations Comparative Analysis of LORETA Z Score Neurofeedback and Cognitive Rehabilitation on Quality of Life and Response Inhibition in Individuals with Opioid Addiction Deep Learning-Based Artificial Intelligence Can Differentiate Treatment-Resistant and Responsive Depression Cases with High Accuracy
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1