Constrained disorder principle-based variability is fundamental for biological processes: Beyond biological relativity and physiological regulatory networks

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2023-07-01 DOI:10.1016/j.pbiomolbio.2023.04.003

Yaron Ilan

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引用次数: 3

Abstract

The constrained disorder principle (CDP) defines systems based on their degree of disorder bounded by dynamic boundaries. The principle explains stochasticity in living and non-living systems. Denis Noble described the importance of stochasticity in biology, emphasizing stochastic processes at molecular, cellular, and higher levels in organisms as having a role beyond simple noise. The CDP and Noble's theories (NT) claim that biological systems use stochasticity. This paper presents the CDP and NT, discussing common notions and differences between the two theories. The paper presents the CDP-based concept of taking the disorder beyond its role in nature to correct malfunctions of systems and improve the efficiency of biological systems. The use of CDP-based algorithms embedded in second-generation artificial intelligence platforms is described. In summary, noise is inherent to complex systems and has a functional role. The CDP provides the option of using noise to improve functionality.

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基于限制性紊乱原理的变异性是生物学过程的基础：超越生物学相关性和生理调控网络

约束无序原理（CDP）根据系统的无序度定义系统，该无序度由动态边界限定。该原理解释了生命系统和非生命系统的随机性。Denis Noble描述了随机性在生物学中的重要性，强调生物体中分子、细胞和更高水平的随机过程具有超越简单噪声的作用。CDP和Noble的理论（NT）声称生物系统使用随机性。本文介绍了CDP和NT，讨论了这两种理论的共同概念和区别。本文提出了基于CDP的概念，即将无序超越其在自然界中的作用，以纠正系统故障并提高生物系统的效率。介绍了基于CDP的算法在第二代人工智能平台中的应用。总之，噪声是复杂系统固有的，具有一定的功能作用。CDP提供了使用噪声来改进功能的选项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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