Automated Whole Cochlear T2 Signal Demonstrates Weak Correlation with Hearing Loss in Observed Vestibular Schwannoma.

IF 1.6 4区医学 Q2 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Audiology and Neuro-Otology Pub Date : 2023-01-01 Epub Date: 2023-06-15 DOI:10.1159/000530567

Nathan D Cass, Yubo Fan, Nathan R Lindquist, Benoit M Dawant, Kareem O Tawfik

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引用次数: 2

Abstract

Introduction: We sought to evaluate the correlation between whole cochlear T2 signal changes obtained with a novel automated segmentation method and hearing levels, both at diagnosis and over time, in patients with observed vestibular schwannoma.

Methods: This retrospective correlation study within an academic medical center neurotology practice evaluated 127 patients with vestibular schwannoma observed over time, each with ≥2 MRI scans (367 total) and ≥2 audiograms (472 total). 86 patients had T2-weighted sequences with sufficient resolution for cochlear signal analysis, yielding 348 unique timepoint intervals. The main outcome measure was correlation of the ipsilateral-to-contralateral ratio of whole cochlear T2 signal with hearing outcomes as measured by pure tone average (PTA) and word recognition score (WRS).

Results: Whole cochlear T2 signal ratios did not show a correlation with hearing levels at diagnosis. Change in signal ratio over time showed weak correlation with changes in PTA, but not WRS, over time. Cochlear signal ratio did not precede changes in hearing but did follow changes in both PTA and WRS.

Conclusion: Whole cochlear T2 signal ratios were weakly correlated with changes in hearing in patients with observed vestibular schwannoma. The technology of automated segmentation and signal processing holds promise for future evaluation of clinical entities causing cochlear signal changes.

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在观察到的前庭神经鞘瘤中，自动全耳蜗T2信号显示出与听力损失的弱相关性。

引言：我们试图评估用一种新的自动分割方法获得的整个耳蜗T2信号变化与观察到的前庭神经鞘瘤患者在诊断时和一段时间内的听力水平之间的相关性。方法：这项在学术医学中心神经科实践中进行的回顾性相关性研究评估了随着时间的推移观察到的127名前庭神经鞘瘤患者，每个患者都进行了≥2次MRI扫描（共367次）和≥2次听力图（共472次）。86名患者的T2加权序列具有足够的分辨率用于耳蜗信号分析，产生348个独特的时间点间隔。主要的结果测量是通过纯音平均值（PTA）和单词识别评分（WRS）测量的整个耳蜗T2信号的同侧与对侧比率与听力结果的相关性。信号比随时间的变化与PTA的变化呈弱相关性，但与WRS的变化无相关性。耳蜗信号比不先于听力变化，而是跟随PTA和WRS的变化。结论：在观察到的前庭神经鞘瘤患者中，整个耳蜗T2信号比与听力变化弱相关。自动分割和信号处理技术有望在未来评估导致耳蜗信号变化的临床实体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Audiology and Neuro-Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： ''Audiology and Neurotology'' provides a forum for the publication of the most-advanced and rigorous scientific research related to the basic science and clinical aspects of the auditory and vestibular system and diseases of the ear. This journal seeks submission of cutting edge research opening up new and innovative fields of study that may improve our understanding and treatment of patients with disorders of the auditory and vestibular systems, their central connections and their perception in the central nervous system. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines.