Monocyte Distribution Width, a Novel Biomarker for Early Sepsis Screening and Comparison with Procalcitonin and C-Reactive Protein.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Journal of Laboratory Physicians Pub Date : 2023-06-01 DOI:10.1055/s-0042-1758666
Fatima Meraj, Sumera Shaikh, Sidra Maqsood, Fatima Kanani, Hamza Khan, Saba Jamal
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引用次数: 1

Abstract

Objectives  Monocyte distribution width (MDW) can be used for the early recognition of sepsis. The study compared the diagnostic accuracy of the MDW with two well-known sepsis biomarkers, procalcitonin (PCT) and C-reactive protein (CRP). Materials and Methods  A study was conducted from July 2021 to October 2021, on 111 patients admitted to the Indus Hospital and Health Network. Patients from the ages of 1 to 90 years were enrolled if hospitalized for more than 24 hours for suspected sepsis to avoid inclusion of patients who had short-term stay in the emergency department. According to the Sequential Organ Failure Assessment score, the clinical team did the characterization of cases as with sepsis or without sepsis. SPSS version 24 was used, and the diagnostic accuracy of MDW was assessed and compared using the area under the curves (AUCs) acquired from receiver operating characteristic curves. Pearson's chi-square/Fisher's exact test (as per need) was applied to determine the association. A p -value of less than 0.05 was considered significant. Results  Among 111 patients, 81 (73%) patients were labeled with sepsis and 30 (27%) were without sepsis. We have reported significantly higher MDW, PCT, and CRP levels in septic patients ( p  < 0.001). The AUC of MDW was comparable with PCT (0.794). Significant cutoff value for the MDW was greater than 20.24 U with 86% sensitivity and 73% specificity. Conclusion  MDW may have a predictive ability similar to PCT and CRP in terms of sepsis and, thus, can be used as a standard parameter for the timely diagnosis of sepsis.

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单核细胞分布宽度:早期脓毒症筛查的新生物标志物及与降钙素原和c反应蛋白的比较。
目的单核细胞分布宽度(MDW)可用于脓毒症的早期识别。该研究比较了MDW与两种众所周知的脓毒症生物标志物降钙素原(PCT)和c反应蛋白(CRP)的诊断准确性。材料和方法研究于2021年7月至2021年10月对印度河医院和健康网络收治的111名患者进行了研究。年龄在1岁到90岁之间的患者,如果因疑似脓毒症住院超过24小时,则被纳入研究,以避免纳入在急诊科短期住院的患者。根据序期器官衰竭评估评分,临床小组对脓毒症或无脓毒症的病例进行了表征。采用SPSS version 24,利用从受试者工作特征曲线获得的曲线下面积(aus)对MDW的诊断准确性进行评估和比较。应用Pearson卡方检验/Fisher精确检验(根据需要)来确定相关性。p值小于0.05为显著性。结果111例患者中有81例(73%)脓毒症,30例(27%)无脓毒症。我们曾报道脓毒症患者MDW、PCT、CRP水平明显增高(p)。结论MDW对脓毒症的预测能力与PCT、CRP类似,可作为脓毒症及时诊断的标准参数。
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来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
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发文量
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审稿时长
31 weeks
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