Luna Vandenbulcke, Margot Erard, Dieter Van Assche, Ellen De Langhe
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引用次数: 0
Abstract
Objective: Fatigue is a prominent and disabling manifestation that impairs the quality of life of Systemic Lupus Erythematosus (SLE) patients both physically and mentally. The majority of SLE patients reports fatigue as an unmet need. Physical exercise could help SLE patients to reduce fatigue and improve quality of life.
Methods: A systematic review was conducted to analyse the effectiveness of physical exercise interventions to reduce fatigue in SLE patients. PubMed, EMBASE, Web of Science: Core Collection, the Cochrane Library, CINAHL via EBSCO, and PEDro were searched (March 2021 to October 2021). Studies were included if they fulfilled prespecified criteria and were assessed for quality using the PEDro risk of bias tool.
Results: A total of 17 studies (11 RCTs, 3 non-RCTs, 2 one-group pretest-posttest designs, and 1 cross-sectional study) were included in this review. They compared exercise treatment with standard care, alternative treatment, or a different type of exercise. Most of the included studies reported significant improvement in fatigue after exercise therapy. However, study heterogeneity is an important methodological limitation. Exercise interventions did not cause disease flare-ups in patients with low to moderate disease activity.
Conclusion: Studies are heterogeneous, precluding firm conclusions. In general, 10 out of 17 studies showed statistically significant but rarely clinically relevant improvement in fatigue after exercise treatment. However, results were not always consistent across different instruments used to assess fatigue. More multi-centred randomised controlled trials are needed to find the best type of physical activity that is both safe and effective for SLE patients.
目的:疲劳是影响系统性红斑狼疮(SLE)患者身心生活质量的一种突出的致残表现。大多数SLE患者报告疲劳是一种未满足的需求。体育锻炼可以帮助SLE患者减轻疲劳，提高生活质量。方法:系统回顾分析体育锻炼干预减轻SLE患者疲劳的有效性。检索PubMed、EMBASE、Web of Science: Core Collection、Cochrane Library、CINAHL via EBSCO和PEDro(2021年3月至2021年10月)。如果研究符合预先规定的标准，并使用PEDro偏倚风险工具评估其质量，则纳入研究。结果:本综述共纳入17项研究(11项随机对照试验，3项非随机对照试验，2项单组前测-后测设计，1项横断面研究)。他们将运动治疗与标准治疗、替代治疗或不同类型的运动进行了比较。大多数纳入的研究报告了运动治疗后疲劳的显著改善。然而，研究异质性是一个重要的方法学限制。在低至中度疾病活动度的患者中，运动干预不会引起疾病发作。结论:研究是异质的，排除了确定的结论。总的来说，17项研究中有10项显示运动治疗后疲劳有统计学意义但很少有临床相关的改善。然而，不同的疲劳评估工具的结果并不总是一致的。需要更多的多中心随机对照试验来找到对SLE患者既安全又有效的最佳体育活动类型。
期刊介绍：
Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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