Evaluation of plasma soluble urokinase plasminogen activator receptor (SuPAR) levels in ulcerative colitis

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Arab Journal of Gastroenterology Pub Date : 2023-08-01 DOI:10.1016/j.ajg.2023.03.001
Huriye Erbak Yılmaz , Saliha Aksun , Süleyman Günay , Ferhan Elmalı , Cem Çekiç
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Abstract

Background and study aim

Soluble urokinase plasminogen activator receptor (SuPAR), a soluble form of the urokinase-type plasminogen activator receptor, is a biomarker produced by macrophages, monocytes, neutrophils, active T cells, endothelial cells, and circulating tumor cells. SuPAR is a novel biomarker showing altered inflammation in many inflammatory diseases. This study aims to investigate the SuPAR level in ulcerative colitis (UC) patients, and to evaluate the SuPAR level in active, and remission patients.

Patients and methods

Patient and healthy control SuPAR levels were analyzed by immunoassay method. SuPAR levels between UC patients and control group were compared. The difference between SuPAR levels in patients with active UC and UC in remission was analyzed. The relationship between C-reactive protein level, Total Mayo score, Mayo Endoscopic score used to predict disease activity, and amount of SuPAR were evaluated.

Results

SuPAR levels were determined in the UC patient group (2170,3 ± 121,0 pg/ml), and healthy controls (2130,7 ± 164,8 pg/ml) (p = 0. 805). Median SuPAR levels were determined in moderate UC (2479 pg/ml), mild UC (1944 pg/ml), and patients in remission (1774 pg/ml) (p = 0,207). There were no significant relationships between SuPAR levels and CRP levels, Total Mayo score, disease duration in the UC group (r = 0.177, r = 0.267, and r = 0,007; respectively p > 0.05). A slightly positive correlation was found between Mayo Endoscopic Score and SuPAR level (r = 0.303; p = 0.031).

Conclusion

SuPAR is of limited value in the diagnosis of ulcerative colitis and in the assessment of disease activation.

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溃疡性结肠炎患者血浆可溶性尿激酶纤溶酶原激活物受体(SuPAR)水平的评估。
背景和研究目的:可溶性尿激酶纤溶酶原激活物受体(SuPAR)是尿激酶型纤溶酶原激活剂受体的一种可溶性形式,是由巨噬细胞、单核细胞、中性粒细胞、活性T细胞、内皮细胞和循环肿瘤细胞产生的生物标志物。SuPAR是一种新的生物标志物,在许多炎症性疾病中显示炎症的改变。本研究旨在调查溃疡性结肠炎(UC)患者的SuPAR水平,并评估活动期和缓解期患者的SuPAR水平。患者和方法:采用免疫测定法分析患者和健康对照组的SuPAR水平。比较UC患者和对照组的SuPAR水平。分析活动期UC患者和缓解期UC患者的SuPAR水平之间的差异。评估C反应蛋白水平、Mayo总分、用于预测疾病活动性的Mayo内镜评分和SuPAR量之间的关系。结果:UC患者组(2170,3±121,0pg/ml)和健康对照组(2130,7±164,8pg/ml)的SuPAR水平均得到测定(p=0。805)。测定中度UC(2479 pg/ml)、轻度UC(1944 pg/ml)和缓解期患者(1774 pg/ml)的中位SuPAR水平(p=0.007)。SuPAR水平与CRP水平、总Mayo评分、总代谢率和总代谢率之间没有显著关系,UC组的病程(r=0.177,r=0.267,r=0007;分别p>0.05)。Mayo内窥镜评分与SuPAR水平呈正相关(r=0.303;p=0.031)。结论:SuPAR在溃疡性结肠炎的诊断和疾病激活评估中的价值有限。
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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
期刊最新文献
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