Predictive Factors of Nonmalignant Pathological Diagnosis and Final Diagnosis of Ultrasound-Guided Cutting Biopsy for Peripheral Pulmonary Diseases.

IF 2.1 4区 医学 Q3 RESPIRATORY SYSTEM Canadian respiratory journal Pub Date : 2023-01-01 DOI:10.1155/2023/5815755
Qing Li, Li Zhang, Xinhong Liao, Yanfen Zhong, Zhixian Li
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Abstract

This study aimed to explore the predictive factors of nonmalignant pathological diagnosis and final diagnosis of ultrasound-guided cutting biopsy for peripheral pulmonary diseases. A total of 470 patients with peripheral lung disease diagnosed as nonmalignant by ultrasound-guided cutting biopsy in the First Affiliated Hospital of Guangxi Medical University from January 2017 to May 2020 were included. Ultrasound biopsy was performed to determine the correctness of pathological diagnosis. Independent risk factors of malignant tumor were predicted by multivariate logistic regression analysis. Pathological biopsy results showed that 162 (34.47%) of the 470 biopsy data were specifically benign, and 308 (65.53%; malignant lesions: 25.3%, benign lesions: 74.7%) were nondiagnostic findings. The final diagnoses were benign in 387 cases and malignant in 83 cases. In the nondiagnostic biopsy malignant risk prediction analysis, lesion size (OR = 1.025, P = 0.005), partial solid lesions (OR = 2.321, P = 0.035), insufficiency (OR = 6.837, P < 0.001), and presence of typical cells (OR = 34.421, P = 0.001) are the final important independent risk factors for malignant tumors. In addition, 30.1% (25/83) of patients with nonmalignant lesions who were finally diagnosed with malignant tumors underwent repeated biopsy, and 92.0% (23/25) were diagnosed during the second repeated biopsy. 59.0% (49/83) received additional invasive examination. Nondiagnostic biopsy predictors of malignant risk include lesion size, partial solid lesions, insufficiency, and presence of atypical cells. When a nonmalignant result is obtained for the first time, the size of the lesion, whether the lesion is subsolid, and the type of pathology obtained should be reviewed.

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超声引导下周围性肺疾病切割活检非恶性病理诊断和最终诊断的预测因素。
本研究旨在探讨超声引导下肺周围性疾病切割活检非恶性病理诊断及最终诊断的预测因素。纳入2017年1月至2020年5月广西医科大学第一附属医院超声引导下活检诊断为非恶性的周围性肺疾病患者470例。行超声活检以确定病理诊断的正确性。采用多因素logistic回归分析预测恶性肿瘤的独立危险因素。病理活检结果显示,470例活检资料中有162例(34.47%)为特异性良性,308例(65.53%);恶性病变:25.3%,良性病变:74.7%)为非诊断性发现。最终诊断为良性387例,恶性83例。在非诊断性活检恶性风险预测分析中,病变大小(OR = 1.025, P = 0.005)、部分实性病变(OR = 2.321, P = 0.035)、功能不全(OR = 6.837, P < 0.001)、典型细胞的存在(OR = 34.421, P = 0.001)是恶性肿瘤最后重要的独立危险因素。此外,30.1%(25/83)的非恶性病变最终诊断为恶性肿瘤的患者进行了重复活检,92.0%(23/25)的患者在第二次重复活检中被诊断出来。59.0%(49/83)接受了额外的有创检查。非诊断性活检的恶性风险预测因素包括病变大小、部分实性病变、功能不全和非典型细胞的存在。当第一次获得非恶性结果时,应回顾病变的大小,病变是否为亚实性,以及所获得的病理类型。
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来源期刊
Canadian respiratory journal
Canadian respiratory journal 医学-呼吸系统
CiteScore
4.20
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.
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