mRNA Regulation by RNA Modifications.

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Annual review of biochemistry Pub Date : 2023-06-20 Epub Date: 2023-04-05 DOI:10.1146/annurev-biochem-052521-035949
Wendy V Gilbert, Sigrid Nachtergaele
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引用次数: 0

Abstract

Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA modifications have been demonstrated to influence nearly every step from the early phases of transcript synthesis in the nucleus through to their decay in the cytoplasm, but in many cases, the molecular mechanisms involved in these processes remain mysterious. Here, we highlight recent work that has elucidated the roles of mRNA modifications throughout the mRNA life cycle, describe gaps in our understanding and remaining open questions, and offer some forward-looking perspective on future directions in the field.

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通过 RNA 修饰调节 mRNA。
mRNA 上的化学修饰是基因表达调控的一个重要层面。在过去十年中,这一领域的研究持续加速,越来越多的修饰被表征出来,其深度和广度也在不断增加。mRNA修饰已被证明影响着从转录本在细胞核中合成的早期阶段到在细胞质中衰变的几乎每一个步骤,但在许多情况下,这些过程所涉及的分子机制仍然是神秘的。在这里,我们将重点介绍最近阐明了 mRNA 修饰在整个 mRNA 生命周期中的作用的研究工作,描述我们在理解上的差距和仍未解决的问题,并对该领域的未来发展方向提出一些前瞻性的观点。
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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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