Anti-malarial plants in Ethiopia and their activities on drug-resistant malaria.

Yimeslal Atnafu Sema, Teshale Areda Waktola
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Abstract

In Ethiopia, the impacts of malaria continue to cause a many number of morbidity and mortality that accounts to most-outpatient observations. Ethiopia recently designed to attain nationwide malaria control by 2030 by beginning sub-national elimination in districts with low malaria transmission. However, the rise of drug-resistant parasites, especially Plasmodium falciparum hinder the malaria-containment strategies. Plasmodium falciparum and Plasmodium vivax are dispersed all over Ethiopia, and account for 60% and 40% of malaria cases, respectively. The aim of this report was to overview the phytochemical constituents, diversity, and effect of some compound extracts on drug-resistant plasmodium species. Many plant species, a total 200 identified by 82 studies, are used in traditional malaria treatments throughout the country. Allium sativum, Croton macrostachyus, and Carica papaya were the more frequently used medicinal plant species. There are so many phytochemical constituents found in medicinal plants used to treat malaria. Alkaloids, flavonoids, phenolics, terpenoids, and glycosides are the most-reported for their effective activity on drug-resistant malaria.

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埃塞俄比亚的抗疟疾植物及其抗耐药性疟疾的活动。
在埃塞俄比亚,疟疾的影响继续造成许多发病率和死亡率,这是大多数门诊观察的结果。埃塞俄比亚最近制定了到2030年实现全国疟疾控制的计划,在疟疾传播率低的地区开始国家级以下的消除工作。然而,耐药寄生虫,特别是恶性疟原虫的增加阻碍了疟疾控制战略。恶性疟原虫和间日疟原虫分布在埃塞俄比亚各地,分别占疟疾病例的60%和40%。本报告的目的是概述植物化学成分,多样性和一些复方提取物对耐药疟原虫的作用。82项研究共确定了200种植物,这些植物在全国各地被用于传统的疟疾治疗。葱、巴豆和番木瓜是使用频率较高的药用植物。在用于治疗疟疾的药用植物中发现了许多植物化学成分。生物碱、黄酮类、酚类、萜类和苷类是报道最多的对耐药疟疾的有效活性。
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CiteScore
3.30
自引率
0.00%
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0
审稿时长
15 weeks
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