The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-03-01 DOI:10.22038/AJP.2022.21512
Sepide Amini, Amirhossein Sahebkar, Alireza Dehghani, Bijan Iraj, Abdolreza Rezaeian-Ramsheh, Gholamreza Askari, Muhammed Majeed, Mohammad Bagherniya
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Abstract

Objective: Curcumin is a safe phytochemical with antioxidant, anti-inflammatory, antidiabetic, and lipid-lowering effects. This study aims to investigate the efficacy of curcumin-piperine in non-proliferative diabetic retinopathy.

Materials and methods: In this double-blind randomized trial, 60 diabetic retinopathy patients after meeting the inclusion criteria will be randomly assigned to two groups of curcumin-piperine supplementation (1000 mg per day for 12 weeks) or receiving placebo. The density of small blood vessels in the retina by optical coherence tomography angiography (OCTA), fasting blood glucose, triglyceride, renal indices (blood urea nitrogen and creatinine), high-sensitivity C-reactive protein, total antioxidant capacity, total oxidant status, body mass index, waist circumference, and weight will be measured.

Conclusion: If the beneficial effects of curcumin on diabetic retinopathy are observed, this safe, this natural and inexpensive herbal supplement can be considered a therapeutic solution in these patients.

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光学相干断层扫描血管造影术(OCTA)中姜黄素-哌啶对非增殖性糖尿病视网膜病变患者心脏代谢、炎症和氧化应激因子以及黄斑血管密度的影响:一项随机、双盲对照试验的研究方案。
目的:姜黄素是一种安全的植物化学物质,具有抗氧化、抗炎、抗糖尿病、降脂等作用。本研究旨在探讨姜黄素哌啶治疗非增殖性糖尿病视网膜病变的疗效。材料和方法:在这项双盲随机试验中,60名符合纳入标准的糖尿病视网膜病变患者将被随机分为两组,分别补充姜黄素-哌啶(每天1000mg,持续12周)或接受安慰剂治疗。通过光学相干断层扫描血管造影术(OCTA)测量视网膜中小血管的密度、空腹血糖、甘油三酯、肾脏指数(血尿素氮和肌酐)、高敏C反应蛋白、总抗氧化能力、总氧化剂状态、体重指数、腰围和体重。结论:如果观察到姜黄素对糖尿病视网膜病变的有益作用,这种安全、天然、廉价的草药补充剂可以被认为是这些患者的治疗方案。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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