Drinking recommended daily water significantly alters haemato-biochemical parameters in prospective blood donors; a one-center quasi-experimental study in a tropical setting

IF 2.1 4区医学 Q3 HEMATOLOGY Blood Cells Molecules and Diseases Pub Date : 2023-09-01 DOI:10.1016/j.bcmd.2023.102757

Bright Kekeli Gbadago , Juliet Antiaye , Joseph Boachie , Patrick Adu

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Abstract

Background

In sub-Saharan Africa, the prevailing high ambient temperatures should warrant increased daily water intake (DWI) to prevent haemo-concentration and its potential to confound patients' laboratory data.

Aim

To assess the impact that the recommended DWI has on the haemato-biochemical variables in a tropical setting.

Materials and methods

This quasi-experimental study recruited 101 apparently healthy individuals (18–60 years) in the Bawku municipality. DWI, anthropometrics, and haemato-biochemical variables were assessed at baseline. Participants were encouraged to increase their DWI to ≥4 L over a 30-day period; haemato-biochemical variables were re-evaluated. Total body water (TBW) was anthropometrically estimated.

Results

The median post-treatment DWI significantly increased; consequently, anaemia cases increased by >20-fold (2.0 % vs 47.5 % post-treatment). RBC count, platelet count, WBC count, and median haemoglobin significantly decreased compared to baseline (p < 0.0001). Biochemically, median plasma osmolality (p < 0.0001), serum sodium (p < 0.0001), serum potassium (p = 0.0012) and random blood sugar (p = 0.0403) significantly decreased. Compared to baseline, significantly higher proportion of participants classified as thrombocytopenic (8.9 % vs 3.0 %), hyponatraemia (10.9 % vs 2.0 %), or normal osmolarity (77.2 % vs 20.8 %). There were differential bivariate correlations between pre- and post-treatment haemato-biochemical variables.

Conclusion

Sub-optimal DWI is a likely confounder in haemato-biochemical data interpretation in the tropics.

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每日饮用推荐的水显著改变了未来献血者的血液生化参数;热带环境下的单中心准实验研究

背景在撒哈拉以南非洲，普遍的高环境温度应该保证每天增加水的摄入量（DWI），以防止血液浓度及其混淆患者实验室数据的可能性。目的评估推荐的DWI对热带环境中血液生化变量的影响。材料和方法这项准实验研究在巴库市招募了101名明显健康的个体（18-60岁）。DWI、人体测量学和血液生化变量在基线时进行评估。鼓励参与者在30天内将DWI增加到≥4L；重新评估血液生化变量。人体总水分（TBW）通过人体测量法进行估算。结果治疗后中位DWI显著升高；因此贫血病例增加>；20倍（2.0%vs 47.5%）。与基线相比，红细胞计数、血小板计数、白细胞计数和中位血红蛋白显著降低（p＜0.0001）。在生物化学方面，中位血浆渗透压（p＜0.001）、血清钠（p＜0.01）、血清钾（p＝0.0012）和随机血糖（p＝0.0403）显著降低。与基线相比，被归类为血小板减少症（8.9%vs 3.0%）、低钠血症（10.9%vs 2.0%）或正常渗透压（77.2%vs 20.8%）的参与者比例明显更高。治疗前和治疗后的血液生化变量之间存在差异的双变量相关性。结论次优DWI可能是热带地区血液生化数据解释的混杂因素。

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来源期刊

Blood Cells Molecules and Diseases 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

14 days

期刊介绍： Blood Cells, Molecules & Diseases emphasizes not only blood cells, but also covers the molecular basis of hematologic disease and studies of the diseases themselves. This is an invaluable resource to all those interested in the study of hematology, cell biology, immunology, and human genetics.