Medium and large alleles of the PGC gene are risk factors for gastric cancer.

Q3 Biochemistry, Genetics and Molecular Biology Tumor Biology Pub Date : 2023-01-01 DOI:10.3233/TUB-220025

Josefina Yoaly Sánchez-López, Katia Carolina Vázquez-Ibarra, Andrea Marlene García-Muro, Azaria García-Ruvalcaba, Sergio Pacheco-Sotelo, Luis Carlos Díaz-Herrera, Marıa Eugenia Marin-Contreras

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Abstract

Background: A 100-bp insertion/deletion polymorphism in the pepsinogen C gene has been associated with the risk of gastric cancer (GC).

Objective: We analyzed the relationships of the 100-bp insertion/deletion polymorphism with GC, atrophic gastritis (AG), and intestinal metaplasia (IM) in the Mexican general population (MGP).

Methods: We studied the genomic DNA of subjects with GC n = 80, AG and IM n = 60, controls n = 110, and the MGP n = 97. PGC gene insertion/deletion polymorphism was identified by means of PCR, capillary electrophoresis and GeneScan software.

Results: Different allele sizes of PGC polymorphism were observed in the studied groups, from 266 bp to 499 bp, which were grouped for the analysis as short alleles of 266-399 bp, medium alleles of 400-433 bp and large alleles of 434-499 bp. Carriers of one or two medium alleles, had an increased risk of GC, with OR of 1.99 (CI95% 1.08-3.67 p = 0.026) compared to homozygotes (no medium/no medium).

Conclusions: Previous studies have related PGC short alleles to risk for or protection against GC depending on the ethnic origin of the population. In our study, medium alleles were related to risk for GC. Further studies are required to establish the importance of this polymorphism in the origin of gastric neoplasia.

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PGC基因中、大等位基因是胃癌发生的危险因素。

背景:胃蛋白酶原C基因的100 bp插入/缺失多态性与胃癌(GC)的风险相关。目的:分析墨西哥普通人群(MGP)中100bp插入/缺失多态性与胃癌、萎缩性胃炎(AG)和肠化生(IM)的关系。方法:研究GC = 80, AG和IM = 60，对照组= 110,MGP = 97的基因组DNA。采用PCR、毛细管电泳和GeneScan软件对PGC基因的插入/缺失多态性进行鉴定。结果:各组PGC多态性等位基因大小在266 ~ 499 bp之间，分为266 ~ 399 bp的短等位基因、400 ~ 433 bp的中等位基因和434 ~ 499 bp的大等位基因。与纯合子(无培养基/无培养基)相比，携带一个或两个中等等位基因的人患胃癌的风险增加，or为1.99 (CI95% 1.08-3.67 p = 0.026)。结论:先前的研究已经将PGC短等位基因与胃癌的风险或预防联系起来，这取决于人群的种族起源。在我们的研究中，中等等位基因与胃癌风险相关。需要进一步的研究来确定这种多态性在胃肿瘤起源中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tumor Biology 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Tumor Biology is a peer reviewed, international journal providing an open access forum for experimental and clinical cancer research. Tumor Biology covers all aspects of tumor markers, molecular biomarkers, tumor targeting, and mechanisms of tumor development and progression. Specific topics of interest include, but are not limited to: Pathway analyses, Non-coding RNAs, Circulating tumor cells, Liquid biopsies, Exosomes, Epigenetics, Cancer stem cells, Tumor immunology and immunotherapy, Tumor microenvironment, Targeted therapies, Therapy resistance Cancer genetics, Cancer risk screening. Studies in other areas of basic, clinical and translational cancer research are also considered in order to promote connections and discoveries across different disciplines. The journal publishes original articles, reviews, commentaries and guidelines on tumor marker use. All submissions are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. Tumor Biology is the Official Journal of the International Society of Oncology and BioMarkers (ISOBM).