The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population.

IF 5.7 2区 医学 Q1 Medicine Clinical Epigenetics Pub Date : 2023-05-17 DOI:10.1186/s13148-023-01502-z
Chien-Yu Lin, Hui-Ling Lee, Ching-Way Chen, Chikang Wang, Fung-Chang Sung, Ta-Chen Su
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Abstract

Background: Adiponectin is a key protein produced in adipose tissue, with crucial involvement in multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the phthalate compounds used as a plasticizer, has been shown to decrease adiponectin levels in vitro and in vivo studies. However, the role of angiotensin I-converting enzyme (ACE) gene polymorphism and epigenetic changes in the relationship between DEHP exposure and adiponectin levels is not well understood.

Methods: This study examined the correlation between urine levels of DEHP metabolite, epigenetic marker 5mdC/dG, ACE gene phenotypes, and adiponectin levels in a sample of 699 individuals aged 12-30 from Taiwan.

Results: Results showed a positive relationship between mono-2-ethylhexyl phthalate (MEHP) and 5mdC/dG, and a negative association between both MEHP and 5mdC/dG with adiponectin. The study found that the inverse relationship between MEHP and adiponectin was stronger when levels of 5mdC/dG were above the median. This was supported by differential unstandardized regression coefficients (- 0.095 vs. - 0.049, P value for interaction = 0.038)). Subgroup analysis also showed a negative correlation between MEHP and adiponectin in individuals with the I/I ACE genotype, but not in those with other genotypes, although the P value for interaction was borderline significant (0.06). The structural equation model analysis indicated that MEHP has a direct inverse effect on adiponectin and an indirect effect via 5mdC/dG.

Conclusions: In this young Taiwanese population, our findings suggest that urine MEHP levels are negatively correlated with serum adiponectin levels, and epigenetic modifications may play a role in this association. Further study is needed to validate these results and determine causality.

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台湾年轻人尿邻苯二甲酸二(2-乙基己基)代谢物与血清脂联素负相关,血管紧张素i转换酶基因多态性与整体DNA甲基化的作用。
背景:脂联素是脂肪组织中产生的一种关键蛋白,在多种代谢过程中起重要作用。邻苯二甲酸二(2-乙基己基)酯(DEHP)是用作增塑剂的邻苯二甲酸酯化合物之一,在体外和体内研究中已被证明可以降低脂联素水平。然而,血管紧张素i转换酶(ACE)基因多态性和表观遗传变化在DEHP暴露与脂联素水平之间的关系中的作用尚不清楚。方法:本研究以台湾地区699名12-30岁人群为样本,检测DEHP代谢物、表观遗传标记物5mdC/dG、ACE基因表型及脂联素水平的相关性。结果:邻苯二甲酸乙二醇酯(MEHP)与5mdC/dG呈正相关,MEHP和5mdC/dG与脂联素呈负相关。研究发现,当5mdC/dG水平高于中位数时,MEHP和脂联素之间的负相关关系更强。差异非标准化回归系数(- 0.095 vs - 0.049,相互作用的P值= 0.038)支持这一点。亚组分析还显示,在I/I ACE基因型个体中,MEHP与脂联素呈负相关,而在其他基因型个体中则无相关,尽管相互作用的P值为临界显著(0.06)。结构方程模型分析表明,MEHP对脂联素具有直接的反向作用,并通过5mdC/dG间接作用。结论:在台湾年轻人群中,我们的研究结果提示尿MEHP水平与血清脂联素水平呈负相关,而表观遗传修饰可能在这种关联中起作用。需要进一步的研究来验证这些结果并确定因果关系。
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来源期刊
Clinical Epigenetics
Clinical Epigenetics Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
8.90
自引率
5.30%
发文量
150
审稿时长
12 weeks
期刊介绍: Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.
期刊最新文献
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