Microglial Characterization in Transient Human Neurodevelopmental Structures.

IF 2.3 4区医学 Q2 DEVELOPMENTAL BIOLOGY Developmental Neuroscience Pub Date : 2023-01-01 Epub Date: 2023-01-05 DOI:10.1159/000528911

David A Menassa, Janja Kopić, Alisa Junaković, Ivica Kostović, Željka Krsnik

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Abstract

Human neurodevelopment is characterized by the appearance, development, and disappearance or transformation of various transient structures that underlie the establishment of connectivity within and between future cortical and subcortical areas. Examples of transient structures in the forebrain (among many others) include the subpial granular layer and the subplate zone. We have previously characterized the precise spatiotemporal dynamics of microglia in the human telencephalon. Here, we describe the diversity of microglial morphologies in the subpial granular layer and the subplate zone. Where possible, we couple the predominant morphological phenotype with functional characterizations to infer tentative roles for microglia in a changing neurodevelopmental landscape. We interpret these findings within the context of relevant morphogenetic and neurogenetic events in humans. Due to the unique genetic, molecular, and anatomical features of the human brain and because many human neurological and psychiatric diseases have their origins during development, these structures deserve special attention.

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瞬时人类神经发育结构中的小胶质细胞特征。

人类神经发育的特点是各种瞬时结构的出现、发展、消失或转变，这些结构是未来皮层和皮层下区域内部和之间建立连接的基础。前脑中的瞬时结构（还有许多其他结构）包括皮层下颗粒层和皮层下区。我们以前曾描述过人类端脑中小胶质细胞的精确时空动态。在这里，我们描述了颗粒层下和板下区小胶质细胞形态的多样性。在可能的情况下，我们将主要的形态表型与功能特征相结合，以推断小胶质细胞在不断变化的神经发育过程中的初步作用。我们结合人类相关的形态发生和神经遗传事件来解释这些发现。由于人脑具有独特的遗传、分子和解剖特征，而且许多人类神经和精神疾病都起源于发育过程，因此这些结构值得特别关注。

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来源期刊

Developmental Neuroscience 医学-发育生物学

CiteScore

4.00

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.