Practical issues of oral immunotherapy for egg or milk allergy.

IF 3.2 Q1 PEDIATRICS Clinical and Experimental Pediatrics Pub Date : 2024-03-01 Epub Date: 2023-06-19 DOI:10.3345/cep.2023.00234
Sukyung Kim, Kangmo Ahn, Jihyun Kim
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Abstract

Oral immunotherapy (OIT) has been recommended to reduce parental burden related to strict allergen avoidance and induce desensitization and immune tolerance for patients with long-lasting allergies to hen's eggs (HE) or cow's milk (CM). OIT should be monitored by pediatric allergists specializing in OIT and oral food challenge tests to manage allergic reactions. Although a previous history of anaphylaxis or multiple food allergies is not a contraindication to OIT, it is contraindicated if the patient has uncontrolled asthma, a malignancy, active systemic autoimmune disorders, or diseases requiring treatment with beta-blockers. A variety of OIT protocols have been de veloped to ensure better outcomes and safe up-dosing, including adjunctive therapies with biologics. This review provides insight into the practical issues of various immunotherapy options for children with HE or CM allergies.

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鸡蛋或牛奶过敏口服免疫疗法的实用问题。
对于对鸡蛋(HE)或牛奶(CM)长期过敏的患者,建议采用口服免疫疗法(OIT)来减轻父母严格回避过敏原的负担,并诱导脱敏和免疫耐受。OIT 应由专门从事 OIT 和口服食物挑战试验的儿科过敏专家进行监控,以控制过敏反应。虽然过敏性休克或多种食物过敏病史并非 OIT 的禁忌症,但如果患者患有未控制的哮喘、恶性肿瘤、活动性全身自身免疫性疾病或需要使用β-受体阻滞剂治疗的疾病,则应禁用 OIT。为了确保更好的疗效和安全的剂量,已经制定了多种 OIT 方案,包括生物制剂的辅助疗法。本综述深入探讨了针对 HE 或 CM 过敏症患儿的各种免疫疗法方案的实际问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.00
自引率
2.40%
发文量
88
审稿时长
60 weeks
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