High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes & Vascular Disease Research Pub Date : 2023-03-01 DOI:10.1177/14791641231169246

Hui Xu, Qun-Yan Xiang, Shuang Li, You-Shuo Liu

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Abstract

Background: Our previous studies have shown that the basic helix-loop-helix family member e40 (Bhlhe40) plays a critical role in regulating calcification and senescence of vascular smooth muscle cells induced by high glucose. In this study, we determined the association between serum Bhlhe40 levels and subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM).

Methods: 247 patients with T2DM were included in this cross-sectional study between June 2021 and July 2022. The presence of subclinical atherosclerosis was evaluated by carotid ultrasonography. Serum Bhlhe40 concentrations were measured with an ELISA kit.

Results: Serum Bhlhe40 levels were remarkably higher in the subclinical atherosclerosis group than in the subjects without subclinical atherosclerosis (p < 0.001). Correlation analysis showed a positive correlation between serum Bhlhe40 and carotid intima-media thickness (C-IMT) (r = 0.155, p = 0.015). The optimal threshold of serum Bhlhe40 > 5.67 ng/mL had an area under the ROC curve (AUC) was 0.709 (p < 0.001). In addition, serum Bhlhe40 levels were associated with the prevalence of subclinical atherosclerosis (OR: 1.790, 95% CI: 1.414-2.266, p < 0.001).

Conclusion: Serum Bhlhe40 levels were significantly higher in T2DM subjects with subclinical atherosclerosis and positively associated with C-IMT.

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高血清Bhlhe40水平与2型糖尿病患者亚临床动脉粥样硬化相关:一项横断面研究

背景:我们前期的研究表明，碱性螺旋-环-螺旋家族成员e40 (Bhlhe40)在调节高糖诱导的血管平滑肌细胞钙化和衰老中起关键作用。在这项研究中，我们确定了2型糖尿病(T2DM)患者血清Bhlhe40水平与亚临床动脉粥样硬化之间的关系。方法:在2021年6月至2022年7月期间，247例T2DM患者被纳入这项横断面研究。通过颈动脉超声检查评估亚临床动脉粥样硬化的存在。采用ELISA试剂盒检测血清Bhlhe40浓度。结果:亚临床动脉粥样硬化组血清Bhlhe40水平明显高于无亚临床动脉粥样硬化组(p < 0.001)。相关性分析显示，血清bhhe40与颈动脉内膜-中膜厚度(C-IMT)呈正相关(r = 0.155, p = 0.015)。血清Bhlhe40 > 5.67 ng/mL的最佳阈值为0.709 (p < 0.001)。此外，血清Bhlhe40水平与亚临床动脉粥样硬化患病率相关(OR: 1.790, 95% CI: 1.414-2.266, p < 0.001)。结论:T2DM合并亚临床动脉粥样硬化患者血清Bhlhe40水平明显升高，且与C-IMT呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)