γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway.

IF 2.7 3区生物学 Hereditas Pub Date : 2023-04-13 DOI:10.1186/s41065-023-00277-w

Ling Xie, Juan Yan

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引用次数: 0

Abstract

Background: Gastric cancer is a common cause of death from cancer and an important global health care issue. Consequently, there is an urgent need to find new drugs and therapeutic targets for the treatment of gastric cancer. Recent studies have shown that tocotrienols (T3) have significant anticancer ability in cancer cell lines. Our previous study found that γ-tocotrienol (γ-T3) induced apoptosis in gastric cancer cells. We further explored the possible mechanisms of γ-T3 therapy for gastric cancer.

Methods: In this study, we treated gastric cancer cells with γ-T3, collect and deposit the cells. γ-T3-treated gastric cancer cells group and untreated group were subjected to RNA-seq assay, and analysis of sequencing results.

Results: Consistent with our previous findings, the results suggest that γ-T3 can inhibit mitochondrial complexes and oxidative phosphorylation. Analysis reveals that γ-T3 has altered mRNA and ncRNA in gastric cancer cells. Significantly altered signaling pathways after γ-T3 treatment were enriched for human papillomavirus infection (HPV) pathway and notch signaling pathway. The same significantly down-regulated genes notch1 and notch2 were present in both pathways in γ-T3-treated gastric cancer cells compared to controls.

Conclusions: It is indicated that γ-T3 may cure gastric cancer by inhibiting the notch signaling pathway. To provide a new and powerful basis for the clinical treatment of gastric cancer.

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γ-生育三烯醇通过notch信号通路调控胃癌。

背景:胃癌是一种常见的癌症死亡原因，也是一个重要的全球卫生保健问题。因此，迫切需要寻找新的治疗胃癌的药物和治疗靶点。近年来的研究表明，生育三烯醇(tocotrienols, T3)对癌细胞具有显著的抗癌作用。我们前期研究发现γ-生育三烯醇(γ-T3)可诱导胃癌细胞凋亡。我们进一步探讨γ-T3治疗胃癌的可能机制。方法:用γ-T3处理胃癌细胞，收集并保存细胞。对γ- t3处理组和未处理组胃癌细胞进行RNA-seq测定，并对测序结果进行分析。结果:与我们之前的研究结果一致，结果表明γ-T3可以抑制线粒体复合物和氧化磷酸化。分析发现，γ-T3改变了胃癌细胞的mRNA和ncRNA。γ-T3处理后，人乳头瘤病毒感染(HPV)通路和notch通路的信号通路发生显著改变。与对照组相比，在γ- t3处理的胃癌细胞中，notch1和notch2基因在这两种途径中均显著下调。结论:γ-T3可能通过抑制notch信号通路治疗胃癌。为胃癌的临床治疗提供新的有力依据。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.