Potential role of exitron-containing homeobox genes in cancer.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2023-05-01 DOI:10.1002/wsbm.1606
Joice de Faria Poloni, Bruno César Feltes
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Abstract

Homeobox genes are protagonists in developmental and cancer biology, making comprehending their regulation pivotal in multiple molecular pathways. Exitrons, also known as intronic exons, are new players in the transcriptional organization, providing additional splicing variants whose functions are still vastly unknown. Exitron splicing sites were identified in eight homeobox genes, which has not been yet debated in the scientific literature. Due to the intimate connection between homeobox genes and tumorigenesis, it is worth investing more time in understanding how these less explored exitron-containing transcriptional isoforms could play a role in modulating the homeobox gene's biological functions. The perspectives devised in this article are meant to instigate fresh debates on how the transcriptional variants retaining exitrons identified in the human homeobox genes HOXA1, HOXA9, HOXD8, NKX3.1, and DLX6 can be examined in the context of tumorigenesis. This article is categorized under: Cancer > Genetics/Genomics/Epigenetics.

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内含外显子的同源盒基因在癌症中的潜在作用。
同源盒型基因是发育和癌症生物学中的主角,在多种分子途径中理解它们的调控至关重要。外显子,也被称为内含子外显子,是转录组织中的新参与者,提供了额外的剪接变体,其功能仍然非常未知。在8个同源盒基因中发现了外显子剪接位点,这在科学文献中尚未引起争论。由于同源盒基因与肿瘤发生之间的密切联系,值得投入更多的时间来了解这些较少被探索的含有外显子的转录异构体如何在调节同源盒基因的生物学功能中发挥作用。本文设计的观点旨在激发关于如何在肿瘤发生的背景下检查人类同源异构体基因HOXA1、HOXA9、HOXD8、NKX3.1和DLX6中保留外显子的转录变异的新争论。本文分类为:癌症>遗传学/基因组学/表观遗传学。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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