The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity.

IF 4.6 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2023-05-01 DOI:10.1002/wsbm.1601

Ruiyao Xu, Wei Xiao, Guanggui Ding, Jiang Zeng, Hui Liu, Yi Cai, Xinchun Chen

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Abstract

Caseous granulomas are pathological hallmarks of tuberculosis (TB), and increasing evidence suggests that TB granuloma composition is highly temporally and spatially heterogenous in both animal models and humans. Traditional pathological techniques are limited in their ability to reveal the heterogeneity present in TB granulomas. Multiplex tissue imaging tools combined with powerful, high resolution spatial analysis have enabled the detection of various cell phenotypes, aiding in the visualization of the granuloma complex and revealing the interactions between immune cells and nonimmune cells. This updated understanding of tuberculous granuloma heterogeneity offers vital insights for researchers aiming to uncover the immunoregulatory mechanisms underlying granuloma formation during TB pathogenesis. More detailed granuloma classification systems will also be of use for precision medicine, and for identifying biological targets for host-directed therapeutics in TB patients. This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Biomedical Engineering Infectious Diseases > Molecular and Cellular Physiology.

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利用多重影像技术表征结核性肉芽肿的异质性。

干酪样肉芽肿是结核病的病理标志，越来越多的证据表明结核肉芽肿的组成在动物模型和人类中具有高度的时间和空间异质性。传统的病理技术在揭示结核肉芽肿的异质性方面是有限的。多种组织成像工具结合强大的高分辨率空间分析，可以检测各种细胞表型，有助于肉芽肿复合体的可视化，并揭示免疫细胞和非免疫细胞之间的相互作用。这种对结核性肉芽肿异质性的最新认识为研究人员揭示结核发病过程中肉芽肿形成的免疫调节机制提供了重要的见解。更详细的肉芽肿分类系统也将用于精准医学，并用于确定结核病患者宿主导向治疗的生物学靶点。本文分类如下:传染病>遗传学/基因组学/表观遗传学传染病>生物医学工程传染病>分子与细胞生理学。

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