Handling missing covariate data in clinical studies in haematology

IF 2.2 4区 医学 Q3 HEMATOLOGY Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI:10.1016/j.beha.2023.101477
Edouard F. Bonneville , Johannes Schetelig , Hein Putter , Liesbeth C. de Wreede
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Abstract

Missing data are frequently encountered across studies in clinical haematology. Failure to handle these missing values in an appropriate manner can complicate the interpretation of a study's findings, as estimates presented may be biased and/or imprecise. In the present work, we first provide an overview of current methods for handling missing covariate data, along with their advantages and disadvantages. Furthermore, a systematic review is presented, exploring both contemporary reporting of missing values in major haematological journals, and the methods used for handling them. A principal finding was that the method of handling missing data was explicitly specified in a minority of articles (in 76 out of 195 articles reporting missing values, 39%). Among these, complete case analysis and the missing indicator method were the most common approaches to dealing with missing values, with more complex methods such as multiple imputation being extremely rare (in 7 out of 195 articles). An example analysis (with associated code) is also provided using hematopoietic stem cell transplantation data, illustrating the different approaches to handling missing values. We conclude with various recommendations regarding the reporting and handling of missing values for future studies in clinical haematology.

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处理血液学临床研究中缺失的协变量数据
临床血液学研究中经常会遇到数据缺失的情况。未能以适当的方式处理这些缺失值可能会使对研究结果的解释复杂化,因为所提供的估计可能存在偏见和/或不精确。在目前的工作中,我们首先概述了当前处理缺失协变量数据的方法,以及它们的优缺点。此外,还对主要血液学期刊中缺失值的当代报道以及处理方法进行了系统综述。主要发现是,少数文章明确规定了处理缺失数据的方法(195篇报告缺失值的文章中有76篇,39%)。其中,完整案例分析和缺失指标法是处理缺失值的最常见方法,而多重插补等更复杂的方法极为罕见(在195篇文章中有7篇)。还提供了使用造血干细胞移植数据的示例分析(带有相关代码),说明了处理缺失值的不同方法。最后,我们就未来临床血液学研究中缺失值的报告和处理提出了各种建议。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.
期刊最新文献
Editorial Board From clones to immunopeptidomes: New developments in the characterization of permissive HLA-DP mismatches in hematopoietic cell transplantation Relevance of donor-specific HLA antibodies in hematopoietic cell transplantation HLA structure and function in hematopoietic-cell transplantation Special issue 37.3: “Genetics and function of HLA and immune-related genes in hematopoietic cell transplantation and cellular immunotherapy”
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