Cisplatin Nephrotoxicity: Novel Insights Into Mechanisms and Preventative Strategies

IF 2.8 3区 医学 Q2 UROLOGY & NEPHROLOGY Seminars in nephrology Pub Date : 2022-11-01 DOI:10.1016/j.semnephrol.2023.151341
Shveta S. Motwani MD, MMSc , Sharneet K. Sandhu MD , Abhijat Kitchlu MD, MSc
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引用次数: 1

Abstract

Cisplatin is a highly effective chemotherapeutic agent that has been used for more than 50 years for a variety of cancers; however, its use is limited by toxicity, including nephrotoxicity. In this in-depth review, we discuss the incidence of cisplatin-associated acute kidney injury, as well as common risk factors for its development. Cisplatin accumulates in the kidney tubules and causes AKI through various mechanisms, including DNA damage, oxidative stress, and apoptosis. We also discuss the spectrum of nephrotoxicity, including acute and chronic impairment of kidney function, electrolyte disturbances, and thrombotic microangiopathy. We discuss the limited options for the diagnosis, prevention, and management of these complications, along with factors that may impact future therapy with or without cisplatin. We conclude with directions for future research in this expanding and important area.

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顺铂肾毒性:机制和预防策略的新见解
顺铂是一种高效的化疗药物,已被用于治疗多种癌症超过50年;然而,它的使用受到毒性的限制,包括肾毒性。在这篇深入的综述中,我们讨论了顺铂相关急性肾损伤的发生率,以及其发展的常见危险因素。顺铂在肾小管中积累,通过多种机制引起AKI,包括DNA损伤、氧化应激和细胞凋亡。我们还讨论了肾毒性的范围,包括急性和慢性肾功能损害、电解质紊乱和血栓性微血管病变。我们讨论了这些并发症的诊断、预防和管理的有限选择,以及可能影响未来顺铂治疗或不顺铂治疗的因素。最后,对这一重要领域的未来研究方向进行了展望。
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来源期刊
Seminars in nephrology
Seminars in nephrology 医学-泌尿学与肾脏学
CiteScore
5.60
自引率
0.00%
发文量
27
审稿时长
6-12 weeks
期刊介绍: Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.
期刊最新文献
Table of Contents Editorial Board Masthead Electronic Collection of Patient-Reported Outcomes to Improve Kidney Care: Benefits, Drawbacks, and Next Steps Patient-Reported Outcomes to Achieve Person-Centered Care for Aging People With Kidney Disease
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