{"title":"Rescue Therapies for AKI in Onconephrology: Rasburicase and Glucarpidase","authors":"Sheron Latcha MD , Chintan V. Shah MD","doi":"10.1016/j.semnephrol.2023.151342","DOIUrl":null,"url":null,"abstract":"<div><p><span>Tumor lysis syndrome (TLS) and high-dose </span>methotrexate<span><span><span><span><span> (HD MTX) toxicity can present with potentially severe complications, including acute kidney injury, </span>in patients with </span>malignancy. Guidelines for using </span>rasburicase and </span>glucarpidase<span> as rescue therapies for TLS and HD MTX toxicity, respectively, are widely used by clinicians intending to mitigate organ toxicity and decrease morbidity and mortality as a consequence of cancer therapy. This review discusses the pathogenesis of TLS and HD MTX–associated toxicity, to understand the mechanism of action of these therapeutic agents and to review the currently available evidence supporting their use.</span></span></p></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"42 6","pages":"Article 151342"},"PeriodicalIF":2.8000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in nephrology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0270929523000529","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Tumor lysis syndrome (TLS) and high-dose methotrexate (HD MTX) toxicity can present with potentially severe complications, including acute kidney injury, in patients with malignancy. Guidelines for using rasburicase and glucarpidase as rescue therapies for TLS and HD MTX toxicity, respectively, are widely used by clinicians intending to mitigate organ toxicity and decrease morbidity and mortality as a consequence of cancer therapy. This review discusses the pathogenesis of TLS and HD MTX–associated toxicity, to understand the mechanism of action of these therapeutic agents and to review the currently available evidence supporting their use.
期刊介绍：
Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.
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